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Submit ReviewMSC 1186
Description: Potent and selective SRPK family inhibitor
Chemical Name: N-[3-[[[2-(6-Chloro-7-fluoro-1H-benzimidazol-2-yl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methylmethanesulfonamide
Purity: ≥98% (HPLC)
Biological Activity for MSC 1186
MSC1186 is a potent and selective inhibitor of serine arginine protein kinases (SRPK) 3, 1 and 2 (IC50 values are 0.6 nM, 3 nM and 81 nM respectively in biochemical assay; EC50 values in NanoBRETassay are 40 nM, 98 nM and 149 nM, respectively). Shows no activity at CLK and DYRK families (IC50 >10 μM).
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MSC 1186 probe summary on the SGC website.
External Portal Information for MSC 1186
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MSC 1186 is reviewed on the chemical probes website.
Technical Data for MSC 1186
| M. Wt | 461.9 |
| Formula | C19H17ClFN7O2S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2871698-23-4 |
| PubChem ID | 162368309 |
| InChI Key | WBFJDKLBAAHKIL-UHFFFAOYSA-N |
| Smiles | O=S(N(C)C1=NC=CC=C1CNC2=NC(C3=NC4=C(N3)C(F)=C(Cl)C=C4)=NC=C2)(C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MSC 1186
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.09 | 50 |
Preparing Stock Solutions for MSC 1186
The following data is based on the product molecular weight 461.9. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.33 mL | 21.65 mL | 43.3 mL |
| 2.5 mM | 0.87 mL | 4.33 mL | 8.66 mL |
| 5 mM | 0.43 mL | 2.16 mL | 4.33 mL |
| 25 mM | 0.09 mL | 0.43 mL | 0.87 mL |
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Product Datasheets for MSC 1186
References for MSC 1186
References are publications that support the biological activity of the product.
Schröder et al (2023) MSC-1186, a highly selective pan-SRPK inhibitor based on an exceptionally decorated benzimidazole-pyrimidine core. J.Med.Chem. 66 837 PMID: 36516476
If you know of a relevant reference for MSC 1186, please let us know.
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Keywords: MSC 1186, MSC 1186 supplier, MSC1186, SRPK, serine, arginine, protein, kinases, kinase, SRPK1, 2, SRPK3, potent, and, selective, Other, Kinases, 7927, Tocris Bioscience
Citations for MSC 1186
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