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Description: Activator of SUMO-activating enzyme, E1 ligase
Chemical Name: 4-Methoxy-N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl-2-benzothiazolamine
Purity: ≥98% (HPLC)
Biological Activity for N106
N106 is an activator of SUMO-activating enzyme, E1 ligase. Increases SERCA2a SUMOylation and activity, and enhances contractility in rat cardiomyocytes in vitro. Improves ventricular function in a mouse model of heart disease.
Technical Data for N106
| M. Wt | 354.38 |
| Formula | C17H14N4O3S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 862974-25-2 |
| PubChem ID | 3236395 |
| InChI Key | FBCSWQRNKAYAGY-UHFFFAOYSA-N |
| Smiles | COC1=C(N=C(NC2=NN=C(C3=CC=C(OC)C=C3)O2)S4)C4=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for N106
References for N106
References are publications that support the biological activity of the product.
Kho et al (2015) Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure. Nat.Commun. 6 7229 PMID: 26068603
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Keywords: N106, N106 supplier, SUMO-activating, enzymes, E1, ligases, SERCA2a, SUMOylation, heart, diseases, activators, Other, Ligases, 5681, Tocris Bioscience
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