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Description: Protects against α-synuclein toxicity; promotes Rsp5/Nedd4-dependent endosomal transport
Chemical Name: N-[(2-Chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-1H-benzimidazole-5-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for NAB 2
NAB 2 protects against α-synuclein toxicity. NAB 2 reverses the α-synuclein-induced pathological phenotype in Parkinson's disease cortical neurons. NAB 2 promotes E3 ubiquitin ligase Rsp5/Nedd4-dependent endosomal transport.
Licensing Information
Sold under license from Whitehead Institute for Biomedical Research.
Technical Data for NAB 2
| M. Wt | 389.88 |
| Formula | C23H20ClN3O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1504588-00-4 |
| PubChem ID | 82017756 |
| InChI Key | CZSLEMCYYGEGKP-UHFFFAOYSA-N |
| Smiles | O=C(NCC4=C(Cl)C=CC=C4)C1=CC=C2C(N=CN2C3=CC(C)=CC=C3C)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for NAB 2
References for NAB 2
References are publications that support the biological activity of the product.
Tardiff et al (2013) Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science 342 979 PMID: 24158909
Chung et al (2013) Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science 342 983 PMID: 24158904
Hatstat et al (2021) Characterization of small-molecule-induced changes in Parkinson's-related trafficking via the Nedd4 ubiquitin signaling cascade. Cell Chem.Biol. 28 14 PMID: 33176158
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Keywords: NAB 2, NAB 2 supplier, NAB2, α, alpha-synuclein, a-synuclein, toxicity, Parkinsons, disease, parkinson's, NEDD4, rsp5, Ubiquitin, E3, Ligases, 5131, Tocris Bioscience
2 Citations for NAB 2
Citations are publications that use Tocris products. Selected citations for NAB 2 include:
Caires-Júnior (2018) Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells. Nat Commun 9 475 PMID: 29396410
Mayana et al (2020) Differential gene expression elicited by ZIKV infection in trophoblasts from congenital Zika syndrome discordant twins. PLoS Negl Trop Dis 14 e0008424 PMID: 32745093
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