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Submit ReviewNicotinamide Riboside
Description: NAD+ precursor; substrate for nicotinamide riboside kinases
Chemical Name: 3-(Aminocarbonyl)-1-β-D-ribofuranosylpyridinium chloride
Purity: ≥98% (HPLC)
Biological Activity for Nicotinamide Riboside
Nicotinamide Riboside is an NAD+ precursor. It is a substrate for nicotinamide riboside kinases (NRK1/2). Nicotinamide Riboside shows neuroprotective effects in a mouse model of type 2 diabetes and improves mitochondrial function in muscle stem cells in aged mice. The compound also corrects non-alchoholic fatty liver disease phenotype induced by NAD+ deficiency or high-fat diet in mice. Orally bioavailable.
Technical Data for Nicotinamide Riboside
| M. Wt | 290.7 |
| Formula | C11H15ClN2O5 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 23111-00-4 |
| PubChem ID | 90480033 |
| InChI Key | YABIFCKURFRPPO-IVOJBTPCSA-N |
| Smiles | NC(C1=C[N+]([C@@H]2O[C@@H]([C@H]([C@H]2O)O)CO)=CC=C1)=O.[Cl-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Nicotinamide Riboside
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.07 | 100 | |
| water | 29.07 | 100 |
Preparing Stock Solutions for Nicotinamide Riboside
The following data is based on the product molecular weight 290.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.44 mL | 17.2 mL | 34.4 mL |
| 5 mM | 0.69 mL | 3.44 mL | 6.88 mL |
| 10 mM | 0.34 mL | 1.72 mL | 3.44 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.69 mL |
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Product Datasheets for Nicotinamide Riboside
References for Nicotinamide Riboside
References are publications that support the biological activity of the product.
Zhang et al (2016) NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science 352 1436 PMID: 27127236
Trammell et al (2016) Nicotinamide riboside opposes type 2 diabetes and neuropathy in mice. Sci.Rep. 6 PMID: 27230286
Zhou et al (2016) Hepatic NAD(+) deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing. Br.J.Pharmacol. 173 2352 PMID: 27174364
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Keywords: Nicotinamide Riboside, Nicotinamide Riboside supplier, NAD+, nicotinamide, riboside, kinase, adenine, dinucleotides, vitamin, precursor, pyridine, nucleoside, NRK1, NRK2, Other, Kinases, Enzyme, Substrates, /, Activators, 6018, Tocris Bioscience
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