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Submit ReviewNorketamine hydrochloride
Description: Potent non-competitive NMDA antagonist; antinociceptive
Chemical Name: 2-Amino-2-(2-chlorophenyl)cyclohexanone hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Norketamine hydrochloride
Norketamine hydrochloride is a major metabolite of ketamine that is a potent non-competitive NMDA receptor antagonist (Ki = 3.6 μM for displacement of [3H]-MK 801 in rat brain). Antinociceptive and anesthetic in vivo.
R-enantiomer and S-enantiomer also available.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for Norketamine hydrochloride
| M. Wt | 260.16 |
| Formula | C12H14ClNO.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 79499-59-5 |
| PubChem ID | 25195026 |
| InChI Key | CLPOJGPBUGCUKT-UHFFFAOYSA-N |
| Smiles | Cl.NC1(CCCCC1=O)C1=C(Cl)C=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Norketamine hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 26.02 | 100 |
Preparing Stock Solutions for Norketamine hydrochloride
The following data is based on the product molecular weight 260.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.84 mL | 19.22 mL | 38.44 mL |
| 5 mM | 0.77 mL | 3.84 mL | 7.69 mL |
| 10 mM | 0.38 mL | 1.92 mL | 3.84 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.77 mL |
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Product Datasheets for Norketamine hydrochloride
References for Norketamine hydrochloride
References are publications that support the biological activity of the product.
Leung et al (1986) Comparative pharmacology in the rat of KA and its two principal metabolites, norKA and (Z)-6-hydroxynorKA. J.Med.Chem. 29 2396 PMID: 3783598
Ebert et al (1997) NorKA, the main metabolite of KA, is a non-competitive NMDA receptor antagonist in the rat cortex and spinal cord. Eur.J.Pharmacol. 333 99 PMID: 9311667
Shimoyama et al (1999) Oral KA is antinociceptive in the rat formalin test: role of the metabolite, norKA. Pain 81 85 PMID: 10353496
If you know of a relevant reference for Norketamine hydrochloride, please let us know.
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Citations for Norketamine hydrochloride
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Literature in this Area
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