Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Review(R)-Norketamine hydrochloride
Description: NMDA receptor modulator; analgesic
Chemical Name: (R)-2-Amino-2-(2-chlorophenyl)cyclohexan-1-one hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for (R)-Norketamine hydrochloride
(R)-Norketamine hydrochloride is a NMDA receptor modulator. Metabolite of Ketamine hydrochloride. Decreases intracellular D-serine concentration (IC50 = 91 nM) and alters serine racemase expression in PC-12 cells. Exhibits analgesic effects in rat pain models.
S-enantiomer and racemate also available.
Technical Data for (R)-Norketamine hydrochloride
| M. Wt | 260.16 |
| Formula | C12H14ClNO.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 83777-68-8 |
| PubChem ID | 71743680 |
| InChI Key | CLPOJGPBUGCUKT-UTONKHPSSA-N |
| Smiles | ClC1=C([C@@]2(N)C(CCCC2)=O)C=CC=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (R)-Norketamine hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 5.2 | 20 | |
| DMSO | 26.02 | 100 |
Preparing Stock Solutions for (R)-Norketamine hydrochloride
The following data is based on the product molecular weight 260.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.84 mL | 19.22 mL | 38.44 mL |
| 5 mM | 0.77 mL | 3.84 mL | 7.69 mL |
| 10 mM | 0.38 mL | 1.92 mL | 3.84 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.77 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for (R)-Norketamine hydrochloride
References for (R)-Norketamine hydrochloride
References are publications that support the biological activity of the product.
Singh et al (2016) KA metabolites enantioselectively decrease intracellular D-serine concentrations in PC-12 cells. PLoS One 11 e0149499 PMID: 27096720
Holtman et al (2008) Effects of norKA enantiomers in rodent models of persistent pain. Pharmacol.Biochem.Behav. 909 676 PMID: 18586315
If you know of a relevant reference for (R)-Norketamine hydrochloride, please let us know.
View Related Products by Target
Keywords: (R)-Norketamine hydrochloride, (R)-Norketamine hydrochloride supplier, NMDA, modulators, modulates, analgesic, ketamine, metabolites, Receptors, Ketamine, and, Metabolites, 5996, Tocris Bioscience
1 Citation for (R)-Norketamine hydrochloride
Citations are publications that use Tocris products. Selected citations for (R)-Norketamine hydrochloride include:
Ago et al (2019) (R)-Ketamine induces a greater increase in prefrontal 5-HT release than (S)-Ketamine and Ketamine Metabolites via an AMPA receptor-independent mechanism. Int J Neuropsychopharmacol 22 665 PMID: 31325908
Do you know of a great paper that uses (R)-Norketamine hydrochloride from Tocris? Please let us know.
Reviews for (R)-Norketamine hydrochloride
There are currently no reviews for this product. Be the first to review (R)-Norketamine hydrochloride and earn rewards!
Have you used (R)-Norketamine hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.