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Submit ReviewPTC 209
Description: Bmi-1 inhibitor; antitumor
Chemical Name: N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-2-thiazolamine
Purity: ≥98% (HPLC)
Biological Activity for PTC 209
PTC 209 is a Bmi-1 inhibitor (IC50 ~ 0.5 μM); irreversibly impairs colorectal cancer-initiating cell (CIC) growth. Reduces tumor growth in CIC xenograft assays and results in reduced potential of colorectal cancer cells to initiate tumors in vivo.
Technical Data for PTC 209
| M. Wt | 495.19 |
| Formula | C17H13Br2N5OS |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 315704-66-6 |
| PubChem ID | 1117196 |
| InChI Key | XVOOCQSWCCRVDY-UHFFFAOYSA-N |
| Smiles | CC3=C(N(C=CC=N4)C4=N3)C1=CSC(NC2=C(Br)C=C(OC)C=C2Br)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PTC 209
References for PTC 209
References are publications that support the biological activity of the product.
Kreso et al (2014) Self-renewal as a therapeutic target in human colorectal cancer. Nat.Med. 20 29 PMID: 24292392
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Keywords: PTC 209, PTC 209 supplier, PTC209, Bmi-1, inhibitors, inhibits, colorectal, cancer-initiating, cell, CIC, growth, polycomb, repressive, complex, 1, PRC1, B, lymphoma, Mo-MLV, insertion, region, homolog, Ubiquitin, E3, Ligases, 5191, Tocris Bioscience
2 Citations for PTC 209
Citations are publications that use Tocris products. Selected citations for PTC 209 include:
Zhaocheng et al (2021) Inverse and reciprocal regulation of p53/p21 and Bmi-1 modulates vasculogenic differentiation of dental pulp stem cells. Cell Death Dis 12 644 PMID: 34168122
Yan et al (2019) The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression. Cancer Cell 36 139-155.e10 PMID: 31327655
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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TPD and Induced Proximity Research Product GuideUpdated
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