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Submit ReviewPZ 3022 is a potent allosteric pantothenate kinase (PanK) activator (EC50=5.3 nM for PanK3). In a mouse model of propionic acidemia, treatment with PZ 3022 increases hepatic CoASH and C2-CoA, and decreases C3-CoA, improving intracellular C3:C2-CoA ratio and plasma C3:C2-carnitine ratios. PZ 3022 is orally bioavailable.
Sold under license from St. Jude Children's Research Hospital
M. Wt | 347.42 |
Formula | C20H21N5O |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 2170608-85-0 |
PubChem ID | 132261124 |
InChI Key | CXSADKGUEBUMLH-UHFFFAOYSA-N |
Smiles | N#CC1=NN=C(N2CCN(CC2)C(CC3=CC=C(C4CC4)C=C3)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 34.74 | 100 |
The following data is based on the product molecular weight 347.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.88 mL | 14.39 mL | 28.78 mL |
5 mM | 0.58 mL | 2.88 mL | 5.76 mL |
10 mM | 0.29 mL | 1.44 mL | 2.88 mL |
50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
References are publications that support the biological activity of the product.
Subramanian et al (2021) Pantothenate kinase activation relieves coenzyme A sequestration and improves mitochondrial function in mice with propionic acidemia. Sci.Transl.Med. 13 eabf5965 PMID: 34524863
If you know of a relevant reference for PZ 3022, please let us know.
Keywords: PZ 3022, PZ 3022 supplier, PZ3022, orally, bioavailable, in, vivo, PZ-3022, hepatic, CoASH, C2-CoA, C3-CoA, C3:C2-CoA, C3:C2-carnitine, carnitine, TCA, cycle, Other, Kinases, 7876, Tocris Bioscience
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