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Submit ReviewRSVA 405
Description: AMPK activator; also STAT3 inhibitor
Chemical Name: 2-[[4-(Diethylamino)-2-hydroxyphenyl]methylene]hydrazide-4-pyridinecarboxylic acid
Purity: ≥98% (HPLC)
Biological Activity for RSVA 405
RSVA 405 is an AMP-activated protein kinase (AMPK) activator (EC50 = 1 μM); activates AMPK indirectly through a CaMKKβ-dependent mechanism. Also inhibits LPS-induced STAT3 phosphorylation (IC50 = 0.5 μM). Induces autophagy and promotes Aβ degradation in vitro. Also inhibits adipogenesis in vitro and reduces weight gain in diet-induced obese mice.
Technical Data for RSVA 405
| M. Wt | 312.37 |
| Formula | C17H20N4O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 140405-36-3 |
| PubChem ID | 9613337 |
| InChI Key | GWQPCBPAOAFXSJ-XDHOZWIPSA-N |
| Smiles | O=C(N/N=C/C2=C(O)C=C(N(CC)CC)C=C2)C1=CC=NC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for RSVA 405
References for RSVA 405
References are publications that support the biological activity of the product.
Vingtdeux et al (2011) Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-beta peptide degradation. FASEB J. 25 219 PMID: 20852062
Vingtdeux et al (2011) Small-molecule activators of AMP-activated protein kinase (AMPK), RSVA314 and RSVA405, inhibit adipogenesis. Mol Med 17 1022 PMID: 21647536
Capiralla et al (2012) Identification of potent small-molecule inhibitors of STAT3 with anti-inflammatory properties in RAW 264.7 macrophages. FASEB J. 279 3791 PMID: 22909341
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Keywords: RSVA 405, RSVA 405 supplier, RSVA405, AMP-activated, protein, kinases, activators, inhibitors, STAT3, indirect, Ab, Abeta, Aβ, amyloid, metabolism, nf-kb, nf-κb, cytokines, inhibits, AMPK, STAT, 5138, Tocris Bioscience
1 Citation for RSVA 405
Citations are publications that use Tocris products. Selected citations for RSVA 405 include:
Dai et al (2017) Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK. Autophagy 13 1435 PMID: 28613987
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