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Submit ReviewSC 66
Description: Allosteric Akt inhibitor
Chemical Name: (2E,6E)-2,6-Bis(4-pyridinylmethylene)cyclohexanone
Purity: ≥98% (HPLC)
Biological Activity for SC 66
SC 66 is an allosteric inhibitor of Akt; interferes with pleckstrin homology domain binding to PIP3 and facilitates Akt ubiquitination. Exhibits anticancer activity in vitro and in vivo.
Technical Data for SC 66
| M. Wt | 276.33 |
| Formula | C18H16N2O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 871361-88-5 |
| PubChem ID | 6018993 |
| InChI Key | CYVVJSKZRBZHAV-UNZYHPAISA-N |
| Smiles | O=C(/C(CCC3)=C/C2=CC=NC=C2)/C3=C/C1=CC=NC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SC 66
References for SC 66
References are publications that support the biological activity of the product.
Jo et al (2011) Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination. Proc.Natl.Acad.Sci.USA 108 6486 PMID: 21464312
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Keywords: SC 66, SC 66 supplier, SC66, akt, pkb, protein, kinase, b, inhibitors, inhibits, allosteric, dual, activity, inhibitory, Akt, (Protein, Kinase, B), Protein, B/Akt, 4398, Tocris Bioscience
2 Citations for SC 66
Citations are publications that use Tocris products. Selected citations for SC 66 include:
Deng et al (2018) HPV16-Immortalized Cells from Human Transformation Zone and Endocervix are More Dysplastic than Ectocervical Cells in Organotypic Culture. Sci Rep 8 15402 PMID: 30337615
Hung et al (2015) p22phox confers resistance to cisplatin, by blocking its entry into the nucleus. J Cell Biol 6 4110 PMID: 25686830
Reviews for SC 66
Average Rating: 5 (Based on 1 Review.)
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SC 66 inhibits LPA induced COX-2 in osteosarcoma cells.
By
Christopher Trummer on 10/23/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: Osteosarcoma
MG-63 cells were treated with LPA (10 µM) alone or in the presence of SC 66 (0-10 µM) for 3 h to follow COX-2 expression using Western blot. SC 66 inhibited LPA-induced COX-2 expression in a concentration dependent manner starting from 5 µM.
Pathways for SC 66
