Home / Pharmacology / Enzymes / Ligases / Ubiquitin E3 Ligases / Ubiquitin E3 Ligase Inhibitors / SJ 1008066

SJ 1008066

Cat. No. 7542 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: MAGE-A11 inhibitor; disrupts MAGE-A11:PCF11 interaction
Chemical Name: N1-((1H-Indol-5-yl)methyl)-N3-(quinolin-4-yl)propane-1,3-diamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for SJ 1008066

SJ 1008066 is a cell permeable inhibitor of testis-restricted melanoma antigen protein MAGE-A11 (IC50 = 0.13 μM). SJ 1008066 binds to the MAGE homology domain (MHD) and disrupts MAGE-A11:PCF11 interaction. SJ1008066 exhibits no effect on MAGE-A3:AMPKα1 or MAGE-F1:MMS19 interactions in TR-FRET and cell lysate pulldown assays.

Licensing Information

Sold under license from St. Jude Children's Research Hospital.

Compound Libraries for SJ 1008066

SJ 1008066 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SJ 1008066

M. Wt 330.44
Formula C21H22N4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2758867-71-7
PubChem ID 162444676
InChI Key UMJWTJVGTTUEQK-UHFFFAOYSA-N
Smiles C12=C(C=CC=C2)C(NCCCNCC3=CC4=C(C=C3)NC=C4)=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SJ 1008066

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.04 100

Preparing Stock Solutions for SJ 1008066

The following data is based on the product molecular weight 330.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.03 mL 15.13 mL 30.26 mL
5 mM 0.61 mL 3.03 mL 6.05 mL
10 mM 0.3 mL 1.51 mL 3.03 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for SJ 1008066

References are publications that support the biological activity of the product.

Yang et al (2020) Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases. Nat.Commun. 11 4931 PMID: 33004795

If you know of a relevant reference for SJ 1008066, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Ubiquitin E3 Ligase Inhibitors

Keywords: SJ 1008066, SJ 1008066 supplier, SJ1008066, cell, permeable, inhibitors, inhibits, testis-restricted, melanoma, antigen, protein, MAGE-A11, disrupts, MAGE-A11:PCF11, interaction, Ubiquitin, E3, Ligases, 7542, Tocris Bioscience

Citations for SJ 1008066

Citations are publications that use Tocris products.

Currently there are no citations for SJ 1008066. Do you know of a great paper that uses SJ 1008066 from Tocris? Please let us know.

Reviews for SJ 1008066

There are currently no reviews for this product. Be the first to review SJ 1008066 and earn rewards!

Have you used SJ 1008066?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia