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SPOP-i-6lc

Cat. No. 7498 Submit a Review Datasheet / COA / SDS
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Description: SPOP E3 ubiquitin ligase inhibitor
Chemical Name: 1,5-Dihydro-2-imino-10-methyl-N-[2-(4-methyl-1-piperazinyl)ethyl]-5-oxo-1-[2-(2-thienyl)ethyl]-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for SPOP-i-6lc

SPOP-i-6lc is a selective SPOP E3 ubiquitin ligase inhibitor (IC50 = 2.1 μM and 3.5 μM, in A498 and OS-RC-2 cell lines, respectively). In vitro, SPOP-i-6lc suppresses viability and proliferation of A498 and OS-RC-2 kidney cancer cell lines. SPOP-i-6lc leads to the accumulation of tumor suppressors PTEN and DUSP7 and decreased levels of phosphorylated AKT and ERK in clear-cell renal cell carcinoma (ccRCC) cell lines.

Technical Data for SPOP-i-6lc

M. Wt 505.64
Formula C26H31N7O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2136270-56-7
PubChem ID 155532456
InChI Key CQWPQOGWIPGPOA-UHFFFAOYSA-N
Smiles CN1CCN(CC1)CCNC(C2=CC3=C(N(C2=N)CCC4=CC=CS4)N=C5N(C3=O)C=CC=C5C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SPOP-i-6lc

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 2.53 5
DMSO 5.06 10

Preparing Stock Solutions for SPOP-i-6lc

The following data is based on the product molecular weight 505.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.78 mL 98.88 mL 197.77 mL
0.5 mM 3.96 mL 19.78 mL 39.55 mL
1 mM 1.98 mL 9.89 mL 19.78 mL
5 mM 0.4 mL 1.98 mL 3.96 mL

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References for SPOP-i-6lc

References are publications that support the biological activity of the product.

Dong et al (2020) Structure-activity relationship of SPOP inhibitors against kidney cancer. J.Med.Chem. 63 4849 PMID: 32297747

If you know of a relevant reference for SPOP-i-6lc, please let us know.

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Keywords: SPOP-i-6lc, SPOP-i-6lc supplier, spopi6lc, SPOP, E3, ubiquitin, ligase, inhibitors, inhibits, kidney, cancer, ligases, ubiquitination, prostate, Ubiquitin, Ligases, 7498, Tocris Bioscience

Citations for SPOP-i-6lc

Citations are publications that use Tocris products.

Currently there are no citations for SPOP-i-6lc. Do you know of a great paper that uses SPOP-i-6lc from Tocris? Please let us know.

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Literature in this Area

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TPD and Induced Proximity Research Product Guide

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