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Takinib

Cat. No. 6430 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective TAK1/MAP3K7 kinase inhibitor
Chemical Name: N1-(1-Propyl-1H-benzimidazol-2-yl)-1,3-benzenedicarboxamide
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Takinib

Takinib is a potent and selective TAK1/MAP3K7 kinase inhibitor (IC50 = 8.2-9.5 nM). Selective for TAK1 over IRAK4, IRAK1, GCK, CLK2 and MINK1 (IC50 values = 120, 390, 430, 430 and 1900 nM, respectively). Demonstrates weak inhibition at Src and Yes1. Exhibits no inhibition of MAP2K or other MAP3K family members. Induces apoptosis following TNF-α stimulation in in vitro models of rheumatoid arthritis and metastatic breast cancer.

Compound Libraries for Takinib

Takinib is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for Takinib

M. Wt 322.37
Formula C18H18N4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1111556-37-6
PubChem ID 37750349
InChI Key UOZVVPXKJGOFIG-UHFFFAOYSA-N
Smiles CCCN1C(NC(C2=CC(C(N)=O)=CC=C2)=O)=NC3=CC=CC=C13

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Takinib

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.24 100

Preparing Stock Solutions for Takinib

The following data is based on the product molecular weight 322.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.1 mL 15.51 mL 31.02 mL
5 mM 0.62 mL 3.1 mL 6.2 mL
10 mM 0.31 mL 1.55 mL 3.1 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References for Takinib

References are publications that support the biological activity of the product.

Totzke et al (2017) Takinib, a selective TAK1 inhibitor, broadens the therapeutic efficacy of TNF-α inhibition for cancer and autoimmune disease. Cell Chem.Biol. 24 1029 PMID: 28820959

If you know of a relevant reference for Takinib, please let us know.

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Citations for Takinib

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