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Description: Selective CK2 inhibitor
Chemical Name: (2E)-3-(2,3,4,5-Tetrabromophenyl)-2-propenoic acid
Purity: ≥98% (HPLC)
Biological Activity for TBCA
TBCA is a selective CK2 inhibitor (IC50 = 110 nM). Exhibits selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases. Reduces viability of Jurkat cells in vitro.
Technical Data for TBCA
| M. Wt | 463.74 |
| Formula | C9H4Br4O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 934358-00-6 |
| PubChem ID | 16760346 |
| InChI Key | SVJQCVOKYJWUBC-OWOJBTEDSA-N |
| Smiles | BrC1=C(/C=C/C(O)=O)C=C(Br)C(Br)=C1Br |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TBCA
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.37 | 100 |
Preparing Stock Solutions for TBCA
The following data is based on the product molecular weight 463.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.16 mL | 10.78 mL | 21.56 mL |
| 5 mM | 0.43 mL | 2.16 mL | 4.31 mL |
| 10 mM | 0.22 mL | 1.08 mL | 2.16 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.43 mL |
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Product Datasheets for TBCA
References for TBCA
References are publications that support the biological activity of the product.
Pagano et al (2007) Tetrabromocinnamic acid (TBCA) and related compounds represent a new class of specific protein kinase CK2 inhibitors. Chembiochem. 8 129 PMID: 17133643
If you know of a relevant reference for TBCA, please let us know.
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Keywords: TBCA, TBCA supplier, selective, casein, kinases, CK2, inhibitors, inhibits, Casein, Kinase, 2, 2825, Tocris Bioscience
1 Citation for TBCA
Citations are publications that use Tocris products. Selected citations for TBCA include:
Shi et al (2015) Acupuncture elicits neuroprotective effect by inhibiting NAPDH oxidase-mediated reactive oxygen species production in cerebral ischaemia. J Virol 5 17981 PMID: 26656460
Do you know of a great paper that uses TBCA from Tocris? Please let us know.
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