Home / Pharmacology / Enzymes / Kinases / ASK1 / ASK1 Inhibitors / TC ASK 10

TC ASK 10

Cat. No. 4825 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective ASK1 inhibitor; orally bioavailable
Chemical Name: 4-(1,1-Dimethylethyl)-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamide dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for TC ASK 10

TC ASK 10 is a potent ASK1 inhibitor (IC50 = 14 nM); displays selectivity for ASK1 over other kinases including ASK2 (IC50 = 0.51 μM), MEKK1, TAK1, IKKβ, ERK1, JNK1, p38α, GSK-3β, PKCθ and B-raf (IC50 values are > 10 μM). Blocks downstream JNK1/p38 phosphorylation in cells. Orally bioavailable.

Compound Libraries for TC ASK 10

TC ASK 10 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for TC ASK 10

M. Wt 432.35
Formula C21H21N5O.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1005775-56-3
PubChem ID 68661090
InChI Key IKKLFEDUYFZNBO-UHFFFAOYSA-N
Smiles O=C(C4=CC=C(C(C)(C)C)C=C4)NC1=CN2C(C=CC(N3C=NC=C3)=C2)=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TC ASK 10

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 43.23 100
DMSO 43.23 100

Preparing Stock Solutions for TC ASK 10

The following data is based on the product molecular weight 432.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.31 mL 11.56 mL 23.13 mL
5 mM 0.46 mL 2.31 mL 4.63 mL
10 mM 0.23 mL 1.16 mL 2.31 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for TC ASK 10

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References for TC ASK 10

References are publications that support the biological activity of the product.

Terao et al (2012) Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors. Bioorg.Med.Chem.Lett. 22 7326 PMID: 23147077

If you know of a relevant reference for TC ASK 10, please let us know.

View Related Products by Target

View Related Products by Product Action

View all ASK1 Inhibitors

Keywords: TC ASK 10, TC ASK 10 supplier, TCASK10, apoptosis, signal, regulating, kinase, ASK1, potent, selective, inhibitors, inhibits, cell, permeable, active, orally, bioavailable, Other, ER, stress/UPR, 4825, Tocris Bioscience

Citations for TC ASK 10

Citations are publications that use Tocris products.

Currently there are no citations for TC ASK 10. Do you know of a great paper that uses TC ASK 10 from Tocris? Please let us know.

Reviews for TC ASK 10

There are currently no reviews for this product. Be the first to review TC ASK 10 and earn rewards!

Have you used TC ASK 10?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.