Home / Pharmacology / Enzymes / Kinases / Polo-like Kinase / Polo-like Kinase Inhibitors / TC-S 7005

TC-S 7005

Cat. No. 4459 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective PLK2 inhibitor
Chemical Name: 3-(1,3-Benzodioxol-5-yl)-N-[(1S)-1-phenylethyl]-isoxazolo[5,4-c]pyridin-5-amine
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for TC-S 7005

TC-S 7005 is a potent and selective polo-like kinase 2 (PLK2) inhibitor (IC50 = 4 nM). Shows selectivity for PLK2 over PLK3 and PLK1 (IC50 values are 24 and 214 nM respectively). Induces mitotic arrest and cell death in HCT 116 colorectal cells.

Compound Libraries for TC-S 7005

TC-S 7005 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for TC-S 7005

M. Wt 359.38
Formula C21H17N3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1082739-92-1
PubChem ID 24971422
InChI Key DAAGOCSHXCDWDY-ZDUSSCGKSA-N
Smiles C[C@H](NC2=CC(C(C4=CC=C(OCO5)C5=C4)=NO3)=C3C=N2)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TC-S 7005

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.94 100

Preparing Stock Solutions for TC-S 7005

The following data is based on the product molecular weight 359.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.78 mL 13.91 mL 27.83 mL
5 mM 0.56 mL 2.78 mL 5.57 mL
10 mM 0.28 mL 1.39 mL 2.78 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets for TC-S 7005

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for TC-S 7005

References are publications that support the biological activity of the product.

Hanan et al (2008) Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors. Bioorg.Med.Chem.Lett. 18 5186 PMID: 18790636

If you know of a relevant reference for TC-S 7005, please let us know.

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1 Citation for TC-S 7005

Citations are publications that use Tocris products. Selected citations for TC-S 7005 include:

Arimoto et al (2023) Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis Nat Commun 14 251 PMID: 36646704

Do you know of a great paper that uses TC-S 7005 from Tocris? Please let us know.

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Literature in this Area

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