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Submit ReviewTGX 221
Description: Potent and selective PI 3-kinase β inhibitor
Chemical Name: 7-Methyl-2-(4-morpholinyl)-9-[1-(phenylamino)ethyl]-4H-pyrido[1,2-a]pyrimidin-4-one
Purity: ≥98% (HPLC)
Biological Activity for TGX 221
TGX 221 is a potent and selective PI 3-kinase β inhibitor (IC50 values are 0.007, 0.1, 3.5 and 5 μM for the β, δ, γ and α isoforms, respectively). Shows >1,000-fold selectively for PI 3-kinase β over a range of other kinases. Inhibits thrombus formation in animal models.
Compound Libraries for TGX 221
TGX 221 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.
Technical Data for TGX 221
| M. Wt | 364.44 |
| Formula | C21H24N4O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 663619-89-4 |
| PubChem ID | 9907093 |
| InChI Key | CPRAGQJXBLMUEL-UHFFFAOYSA-N |
| Smiles | CC(C1=CC(C)=CN2C(C=C(N3CCOCC3)N=C12)=O)NC4=CC=CC=C4 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TGX 221
References for TGX 221
References are publications that support the biological activity of the product.
Condliffe et al (2005) Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood 106 1432 PMID: 15878979
Jackson et al (2005) PI 3-kinase p110β: a new target for antithrombotic therapy. Nat.Med. 11 507 PMID: 15834429
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Keywords: TGX 221, TGX 221 supplier, TGX221, PI3K, PI, 3-kinase, phosphoinositide, potent, selective, inhibits, inhibitors, beta, β, antithrombotic, 3-Kinase, 5832, Tocris Bioscience
Citations for TGX 221
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Currently there are no citations for TGX 221.
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