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VL 285

Cat. No. 7903 Submit a Review Datasheet / COA / SDS
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Description: VHL inhibitor
Chemical Name: (2S,4R)-4-Hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature (3)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for VL 285

VL 285 is an E3 ubiquitin ligase VHL inhibitor (IC50= 340 nM). VL 285 treatment competitively reduces or reverses target protein degradation by AU-15330 and HaloPROTAC3 Degraders.

Technical Data for VL 285

M. Wt 532.66
Formula C29H32N4O4S
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1448188-57-5
PubChem ID 71667162
InChI Key HEDFFPYRFJKXQP-VJTSUQJLSA-N
Smiles CC1=C(C2=CC=C(CNC([C@H]3N(C([C@@H](N4CC(C=CC=C5)=C5C4=O)C(C)C)=O)C[C@H](O)C3)=O)C=C2)SC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for VL 285

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.63 50
ethanol 10.65 20

Preparing Stock Solutions for VL 285

The following data is based on the product molecular weight 532.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.75 mL 18.77 mL 37.55 mL
2.5 mM 0.75 mL 3.75 mL 7.51 mL
5 mM 0.38 mL 1.88 mL 3.75 mL
25 mM 0.08 mL 0.38 mL 0.75 mL

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References for VL 285

References are publications that support the biological activity of the product.

Buckley et al (2015) HaloPROTACS: use of small molecule PROTACs to induce degradation of HaloTag fusion proteins. ACS Chem.Biol. 10 1831 PMID: 26070106

Xiao et al (2022) Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer. Nature 601 434 PMID: 34937944

If you know of a relevant reference for VL 285, please let us know.

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Citations for VL 285

Citations are publications that use Tocris products.

Currently there are no citations for VL 285. Do you know of a great paper that uses VL 285 from Tocris? Please let us know.

Reviews for VL 285

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia