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1,2,3,4,5,6-Hexabromocyclohexane

Cat. No. 2291 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2291 has been discontinued.

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说明： Inhibits JAK2 autophosphorylation
别名： NSC 7908
化学名： 1,2,3,4,5,6-Hexabromocyclohexane
说明书
引用文献 (1)
评论
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for 1,2,3,4,5,6-Hexabromocyclohexane

Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1 μM of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μM elimates nearly all JAK2 activity. Non-cytotoxic at 100 μM.

技术数据 for 1,2,3,4,5,6-Hexabromocyclohexane

分子量 557.54
公式 C6H6Br6
储存 Store at RT
CAS Number 1837-91-8
PubChem ID 74603
InChI Key QFQZKISCBJKVHI-UHFFFAOYSA-N
Smiles BrC1C(C(C(C(C1Br)Br)Br)Br)Br

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for 1,2,3,4,5,6-Hexabromocyclohexane

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参考文献 for 1,2,3,4,5,6-Hexabromocyclohexane

参考文献是支持产品生物活性的出版物。

Sandberg et al (2005) Identification of 1,2,3,4,5,6-Hexabromocyclohexane as a small molecule inhibitor of Jak2 tyrosine kinase autophosphorylation. J.Med.Chem. 48 2526 PMID: 15801842

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关键词: 1,2,3,4,5,6-Hexabromocyclohexane, 1,2,3,4,5,6-Hexabromocyclohexane supplier, inhibitors, inhibits, JAK2, autophosphorylation, Kinases, Janus, Activated, NSC7908, NSC, 7908, JAK, Kinase, 2291, Tocris Bioscience

1 篇 1,2,3,4,5,6-Hexabromocyclohexane 的引用文献

引用文献是使用了 Tocris 产品的出版物。 1,2,3,4,5,6-Hexabromocyclohexane 的部分引用包括：

Rogers and Gahring (2015) Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways. Genes Dev 10 e0143319 PMID: 26619345

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Pathways for 1,2,3,4,5,6-Hexabromocyclohexane

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.