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10-DEBC hydrochloride

Cat. No. 2558 6 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective Akt/PKB inhibitor
别名： Akt Inhibitor X
化学名： 10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride
纯度： ≥99% (HPLC)
说明书
引用文献 (6)
评论 (1)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for 10-DEBC hydrochloride

10-DEBC hydrochloride is a selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC50 ~ 2-6 μM) and induces apoptosis in rhabdomyosarcoma cells.

化合物库 for 10-DEBC hydrochloride

10-DEBC hydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for 10-DEBC hydrochloride

分子量 381.34
公式 C20H25N2OCl.HCl
储存 Desiccate at +4°C
纯度 ≥99% (HPLC)
CAS Number 925681-41-0
PubChem ID 16760284
InChI Key SVKSJUIYYCQZEC-UHFFFAOYSA-N
Smiles Cl.CCN(CC)CCCCN1C2=CC=CC=C2OC2=C1C=C(Cl)C=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 10-DEBC hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 38.13 100
DMSO 38.13 100

制备储备液 for 10-DEBC hydrochloride

以下数据基于产品分子量 381.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.62 mL 13.11 mL 26.22 mL
5 mM 0.52 mL 2.62 mL 5.24 mL
10 mM 0.26 mL 1.31 mL 2.62 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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产品说明书 for 10-DEBC hydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for 10-DEBC hydrochloride

参考文献是支持产品生物活性的出版物。

Thimmaiah et al (1992) Synthesis and chemical characterization of N-substituted phenoxazines directed toward reversing vinca alkaloid resistance in multidrug-resistant cancer cells. J.Med.Chem. 35 3358 PMID: 1527786

Thimmaiah et al (2005) Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling. J.Biol.Chem. 36 31924

If you know of a relevant reference for 10-DEBC hydrochloride, please let us know.

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关键词: 10-DEBC hydrochloride, 10-DEBC hydrochloride supplier, Selective, Akt, PKB, inhibitors, inhibits, Protein, Kinase, B, Kinases, Inhibitor, X, (Protein, B), B/Akt, 2558, Tocris Bioscience

6 篇 10-DEBC hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 10-DEBC hydrochloride 的部分引用包括：

Ali et al (2017) Isolation and characterization of a new naturally immortalized human breast carcinoma cell line, KAIMRC1. BMC Cancer 17 803 PMID: 29187162

Sokołowska et al (2014) Orexins protect neuronal cell cultures against hypoxic stress: an involvement of Akt signaling. PLoS One 52 48 PMID: 24243084

Waltero et al (2019) TOR as a Regulatory Target in Rhipicephalus microplus Embryogenesis. Front Physiol 10 965 PMID: 31417424

Gangoiti et al (2012) Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts. Biochimie 94 597 PMID: 21945811

Goodnough et al (2012) Inhibition of hepcidin transcription by growth factors. Hepatology 56 291 PMID: 22278715

Liddell et al (2016) Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes. J Neuroinflammation 13 49 PMID: 26920699

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Inhibition of Akt/PKB in BV2 microglia cells.
By Joanna Plastira on 06/08/2019
分析类型： In Vitro
种属： Mouse
细胞系/组织： BV2 microglia cells

As part of our current study, we investigated the role of AKT pathway on the LPA induced inflammatory phenotype in microglia (downstream signaling). BV2 cells were incubated for different time points with LPA (1µM) in the presence or absence of AKT X (5µM). AKT inhibition totally decreased the expression of 2 pro-inflammatory transcription factors (pSTAT1 and pp65). The inhibitor was diluted in water.

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Pathways for 10-DEBC hydrochloride

Akt Signaling Pathway

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.