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A12B4C3

Cat. No. 5097 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective polynucleotide kinase/phosphatase (PNKP) inhibitor
化学名： 4a,7a-Dihydro-2-(1-hydroxyundecyl)-1-[(4-nitrophenyl)amino]-6-phenyl-1H-pyrrolo[3,4-b]pyridine-5,7(2H,6H)-dione
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for A12B4C3

A12B4C3 is a potent and selective polynucleotide kinase/phosphatase (PNKP) inhibitor (IC50 = 60 nM). Displays no effect on calcineurin, protein PP-1 or APTX. Interrupts DNA repair and enhances radiosensitivity of human A549 lung carcinoma and MDA-MB-231 cells.

化合物库 for A12B4C3

A12B4C3 is also offered as part of the Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for A12B4C3

分子量 534.65
公式 C30H38N4O5
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1005129-80-5
PubChem ID 6610064
InChI Key KVHGJAKTBPFFNV-UHFFFAOYSA-N
Smiles O=C2N(C4=CC=CC=C4)C(C1C=CC(C(O)CCCCCCCCCC)N(NC3=CC=C([N+]([O-])=O)C=C3)C12)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for A12B4C3

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 53.47 100

制备储备液 for A12B4C3

以下数据基于产品分子量 534.65。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.87 mL 9.35 mL 18.7 mL
5 mM 0.37 mL 1.87 mL 3.74 mL
10 mM 0.19 mL 0.94 mL 1.87 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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参考文献 for A12B4C3

参考文献是支持产品生物活性的出版物。

Freschauf et al (2009) Identification of a small molecule inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphatase. Cancer Res. 69 7739 PMID: 19773431

Freschauf et al (2010) Mechanism of action of an imidopiperidine inhibitor of human polynucleotide kinase/phosphatase. J.Biol.Chem. 285 2351 PMID: 19940137

Schellenberg et al (2011) DNA end processing by polynucleotide kinase/phosphatase. Proc.Natl.Acad.Sci.U.S.A. 108 20855 PMID: 22184240

If you know of a relevant reference for A12B4C3, please let us know.

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关键词: A12B4C3, A12B4C3 supplier, Potent, selective, polynucleotide, kinases, phosphatases, PKNP, inhibitors, inhibits, DNA, repair, Other, Kinases, 5097, Tocris Bioscience

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