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A66

Cat. No. 5595 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective PI 3-kinase p110α inhibitor
化学名： (2S)-N1-[2-(1,1-Dimethylethyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for A66

A66 is a potent and selective PI 3-kinase p110α inhibitor (IC50 = 32 nM). Exhibits >100-fold selectivity for p110α over other PI 3-kinase isoforms. Inhibits Akt signaling and tumor growth in SK-OV-3 xenografts in mice.

化合物库 for A66

A66 is also offered as part of the Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for A66

分子量 393.53
公式 C17H23N5O2S2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1166227-08-2
PubChem ID 42636535
InChI Key HBPXWEPKNBHKAX-NSHDSACASA-N
Smiles CC(C)(C)C1=NC(C2=C(C)N=C(NC(N3[C@H](C(N)=O)CCC3)=O)S2)=CS1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for A66

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 39.35 100

制备储备液 for A66

以下数据基于产品分子量 393.53。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.71 mL 25.41 mL
5 mM 0.51 mL 2.54 mL 5.08 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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参考文献 for A66

参考文献是支持产品生物活性的出版物。

Jamieson et al (2011) A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types. Biochem. J. 438 53 PMID: 21668414

If you know of a relevant reference for A66, please let us know.

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关键词: A66, A66 supplier, PI, 3-kinase, PI3K, phosphoinositide, inhibitors, potent, selective, inhibits, p110a, alpha, α, 3-Kinase, 5595, Tocris Bioscience

3 篇 A66 的引用文献

引用文献是使用了 Tocris 产品的出版物。 A66 的部分引用包括：

Tania et al (2021) Growth and Viability of Cutaneous Squamous Cell Carcinoma Cell Lines Display Different Sensitivities to Isoform-Specific Phosphoinositide 3-Kinase Inhibitors. Int J Mol Sci 22 PMID: 33808215

Christos et al (2021) Dominant Role of PI3K p110α over p110β in Insulin and β-Adrenergic Receptor Signalling. Int J Mol Sci 22 PMID: 34884613

Eugene et al (2020) Increased mitochondrial and lipid metabolism is a conserved effect of Insulin/PI3K pathway downregulation in adipose tissue. Sci Rep 10 3418 PMID: 32099025

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