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AIM 100

Cat. No. 4946 2 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective Ack1 (TNK2) inhibitor
化学名： 5,6-Diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]furo[2,3-d]pyrimidin-4-amine
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论 (1)
文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AIM 100

AIM 100 is a potent Ack1 (TNK2) inhibitor (IC50 = 22 nM). Exhibits selectivity for Ack1 over ABL1, BTK, Lck and LYN; exhibits no inhibition of 25 other kinases. Suppresses phosphorylation of Tyr267 of the androgen receptor in prostate cancer cells. Also suppresses growth of radioresistant castration-resistant prostate cancer in xenograft tumors in mice. Also promotes DAT endocytosis and oligomerization.

化合物库 for AIM 100

AIM 100 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for AIM 100

分子量 371.43
公式 C23H21N3O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 873305-35-2
PubChem ID 11501591
InChI Key XNFHHOXCDUAYSR-SFHVURJKSA-N
Smiles C1(C(C4=CC=CC=C4)=C(C5=CC=CC=C5)O3)=C3N=CN=C1NC[C@H]2OCCC2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AIM 100

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 37.14 100
ethanol 37.14 100

制备储备液 for AIM 100

以下数据基于产品分子量 371.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.46 mL 26.92 mL
5 mM 0.54 mL 2.69 mL 5.38 mL
10 mM 0.27 mL 1.35 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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产品说明书 for AIM 100

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for AIM 100

参考文献是支持产品生物活性的出版物。

Mahajan et al (2012) Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer. J.Biol.Chem. 287 22112 PMID: 22566699

Mahajan et al (2010) Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity. Prostate 70 1274 PMID: 20623637

Sorkina et al (2018) Small molecule induced oligomerization, clustering and clathrin-independent endocytosis of the dopamine transporter. Elife. 7 PMID: 29630493

If you know of a relevant reference for AIM 100, please let us know.

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关键词: AIM 100, AIM 100 supplier, AIM100, ack1, inhibitors, inhibits, selective, kinases, TNK2, tyrosine, kinase, non-receptor, Androgen, Receptor, Ack1, Dopamine, Transporters, 4946, Tocris Bioscience

2 篇 AIM 100 的引用文献

引用文献是使用了 Tocris 产品的出版物。 AIM 100 的部分引用包括：

Verduzco et al (2018) Ceritinib Enhances the Efficacy of Trametinib in BRAF/NRAS-Wild-Type Melanoma Cell Lines. Mol Cancer Ther 17 73 PMID: 29133622

Guy A et al (2022) Systemic RNA Interference Defective (SID) genes modulate dopaminergic neurodegeneration in C. elegans. PLoS Genet 18 e1010115 PMID: 35984862

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AIM 100 的评论

平均评分: 5 (Based on 1 Review.)

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Inhibition of MEK and ACK1 suppresses long-term growth of WM209 and SK-MEL-23 cells..
By Anonymous on 11/09/2019
分析类型： In Vitro
种属： Human
细胞系/组织： WM209 and SK-MEL-23 cells

Combined pharmacological inhibition of MEK and ACK1 suppresses long-term growth of WM209 and SK-MEL-23 cells.

PMID: 29133622
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