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Amlexanox

Cat. No. 4857 4 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective inhibitor of TBK
化学名： 2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid
纯度： ≥99% (HPLC)
说明书
引用文献 (4)
评论
文献 (2)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Amlexanox

Amlexanox is a selective inhibitor of TANK-binding kinase 1 (TBK1) and IKKε (IC50 values are ~1-2 μM). Displays no effect on IKKα or IKKβ at these concentrations. Reversibly lowers weight, increases insulin sensitivity, and reduces inflammation and steatosis in three mouse models of obesity. Exhibits antiallergic activity; inhibits the release of histamine from rat mast cells. Also binds to Hsp90 and inhibits C-terminal chaperone activity in vitro.

化合物库 for Amlexanox

Amlexanox is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Amlexanox

分子量 298.29
公式 C16H14N2O4
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 68302-57-8
PubChem ID 2161
InChI Key SGRYPYWGNKJSDL-UHFFFAOYSA-N
Smiles CC(C)C1=CC=C2C(C(C(C=C(C(O)=O)C(N)=N3)=C3O2)=O)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Amlexanox

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 29.83 100

制备储备液 for Amlexanox

以下数据基于产品分子量 298.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.35 mL 16.76 mL 33.52 mL
5 mM 0.67 mL 3.35 mL 6.7 mL
10 mM 0.34 mL 1.68 mL 3.35 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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参考文献 for Amlexanox

参考文献是支持产品生物活性的出版物。

Reilly et al (2012) An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice. Nat.Med. 19 313 PMID: 23396211

Okada et al (2003) Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amle. Biochem.J. 374 433 PMID: 12803546

Makino et al (1987) Mechanism of action of an antiallergic agent, amle. (AA-673), in inhibiting histamine release from mast cells. Acceleration of cAMP generation and inhibition of phosphodiesterase. Int.Arch.Allergy Appl.Immunol. 82 66 PMID: 2433225

If you know of a relevant reference for Amlexanox, please let us know.

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关键词: Amlexanox, Amlexanox supplier, diabetes, obese, obesity, mouse, mice, anti-inflammatory, anti-inflammatories, metabolic, disorders, diseases, IkB, kinase, IkappaB, IκB, IKK, TBK1, TANK-binding, 1, noncanonical, Kinase, NF-kB/IkB, Histaminergic-Related, Compounds, TANK, binding, (TBK), 4857, Tocris Bioscience

4 篇 Amlexanox 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Amlexanox 的部分引用包括：

Neysan et al (2021) Genotoxic stress in constitutive trisomies induces autophagy and the innate immune response via the cGAS-STING pathway. Commun Biol 4 831 PMID: 34215848

Lin et al (2021) A naturally derived small molecule NDSM253 inhibits IKK1 to suppress inflammation response and promote bone healing after fracture. Am J Transl Res 13 24-37 PMID: 33527006

Harold I et al (2021) Tank Binding Kinase 1 modulates spindle assembly checkpoint components to regulate mitosis in breast and lung cancer cells. Biochim Biophys Acta Mol Cell Res 1868 118929 PMID: 33310066

Alrahbeni et al (2015) Full UPF3B function is critical for neuronal differentiation of neural stem cells. Br J Pharmacol 8 33 PMID: 26012578

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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Pathways for Amlexanox

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Toll-like Receptor Signaling Pathway

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