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Submit ReviewAR-A 014418
说明： Selective GSK-3 inhibitor
化学名： N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea
纯度： ≥99% (HPLC)
生物活性 for AR-A 014418
AR-A 014418 is a selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.
许可信息
Sold with the permission of AstraZeneca UK Ltd.
化合物库 for AR-A 014418
AR-A 014418 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。
技术数据 for AR-A 014418
| 分子量 | 308.31 |
| 公式 | C12H12N4O4S |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 487021-52-3 |
| PubChem ID | 448014 |
| InChI Key | YAEMHJKFIIIULI-UHFFFAOYSA-N |
| Smiles | O=C(NCC2=CC=C(OC)C=C2)NC1=NC=C([N+]([O-])=O)S1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for AR-A 014418
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 30.83 | 100 | |
| ethanol | 1.54 | 5 |
制备储备液 for AR-A 014418
以下数据基于产品分子量 308.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.24 mL | 16.22 mL | 32.43 mL |
| 5 mM | 0.65 mL | 3.24 mL | 6.49 mL |
| 10 mM | 0.32 mL | 1.62 mL | 3.24 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.65 mL |
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产品说明书 for AR-A 014418
参考文献 for AR-A 014418
参考文献是支持产品生物活性的出版物。
Bhat and Budd (2002) GSK3β signalling: casting a wide net in Alzheimer's disease. Neurosignals 11 251 PMID: 12566926
Bhat et al (2003) Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. J.Biol.Chem. 278 45937 PMID: 12928438
Gould et al (2004) AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test. Int.J.Neuropsychopharmacol. 7 387 PMID: 15315719
If you know of a relevant reference for AR-A 014418, please let us know.
按产品操作查看相关产品
关键词: AR-A 014418, AR-A 014418 supplier, ARA014418, glycogen, synthase, kinase, 3, GSK-3, GSK3, inhibitors, inhibits, Glycogen, Synthase, Kinase, 3966, Tocris Bioscience
4 篇 AR-A 014418 的引用文献
引用文献是使用了 Tocris 产品的出版物。 AR-A 014418 的部分引用包括：
Ling et al (2019) Interleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site. J Neuroinflammation 16 275 PMID: 31882005
Penas et al (2015) GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation. Tuberc Respir Dis (Seoul) 14 417 PMID: 25616418
Cuesto et al (2015) GSK3β Inhibition Promotes Synaptogenesis in Drosophila and Mammalian Neurons. PLoS One 10 e0118475 PMID: 25764078
Chen et al (2012) Spatially coordinated kinase signaling regulates local axon degeneration. J Neurosci 32 13439 PMID: 23015435
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Pathways for AR-A 014418
