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Atiprimod dihydrochloride

Cat. No. 4580 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4580 has been discontinued.

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说明： JAK2 inhibitor
化学名： N,N-Diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamine dihydrochloride
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for Atiprimod dihydrochloride

Atiprimod dihydrochloride is a JAK2 inhibitor (IC50 = 397 nM). Also inhibits STAT3 and STAT5 phosphorylation. Inhibits cell growth and induces apoptosis in cells expressing the JAK2V617F mutation.

技术数据 for Atiprimod dihydrochloride

分子量 409.52
公式 C22H44N2.2HCl
储存 Desiccate at RT
CAS Number 130065-61-1
PubChem ID 166556
InChI Key MOUZYBYTICOTFQ-UHFFFAOYSA-N
Smiles CCCC1(CCC)CCC2(CN(CCCN(CC)CC)CC2)CC1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Atiprimod dihydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Atiprimod dihydrochloride

参考文献是支持产品生物活性的出版物。

Manshouri et al (2011) Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the effects of a JAK2 inhibitor. Cancer Res. 71 3831 PMID: 21512135

Quintás-Cardama et al (2011) Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor. Invest.New Drugs 29 818 PMID: 20372971

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关键词: Atiprimod dihydrochloride, Atiprimod dihydrochloride supplier, JAK2, kinases, inhibitors, inhibits, induces, apoptosis, proapoptotic, janus, activated, STAT3, STAT5, JAK, Kinase, 4580, Tocris Bioscience

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Pathways for Atiprimod dihydrochloride

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.