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Autophinib

Cat. No. 6324 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent VPS34 inhibitor
化学名： 6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-pyrimidinamine
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Autophinib

Autophinib is a potent VPS34 (class III PI 3-kinase) inhibitor (IC50 = 19 nM). Inhibits starvation- and Rapamycin-induced autophagy (IC50 values = 40 and 90 nM, respectively).

化合物库 for Autophinib

Autophinib is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Autophinib

分子量 346.73
公式 C14H11ClN6O3
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1644443-47-9
PubChem ID 129626605
InChI Key CEUMAXLRGBKFQP-UHFFFAOYSA-N
Smiles CC1=CC(NC2=NC(OC3=CC=C([N+]([O-])=O)C=C3)=NC(Cl)=C2)=NN1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Autophinib

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 6.93 20

制备储备液 for Autophinib

以下数据基于产品分子量 346.73。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 14.42 mL 72.1 mL 144.2 mL
1 mM 2.88 mL 14.42 mL 28.84 mL
2 mM 1.44 mL 7.21 mL 14.42 mL
10 mM 0.29 mL 1.44 mL 2.88 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for Autophinib

参考文献是支持产品生物活性的出版物。

Richters et al (2015) Identification and further development of potent TBK1 inhibitors. ACS Chem Biol. 10 289 PMID: 25540906

Robke et al (2017) Phenotypic identification of a novel autophagy inhibitor chemotype targeting lipid kinase VPS34. Angew.Chem.Int.Ed.Engl. 56 8153 PMID: 28544137

If you know of a relevant reference for Autophinib, please let us know.

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关键词: Autophinib, Autophinib supplier, Potent, autophagy, inhibitors, inhibits, VPS34, vacuolar, protein, sorting, 34, PI, 3-K, 3-kinase, Autophagy, 3-Kinase, 6324, Tocris Bioscience

1 篇 Autophinib 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Autophinib 的部分引用包括：

Dominique et al (2021) TFEB phosphorylation on Serine 211 is induced by autophagy in human synovial fibroblasts and by p62/SQSTM1 overexpression in HEK293 cells. Biochem J 478 3145-3155 PMID: 34405859

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Autophinib 的评论

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