AZ 20

Cat. No. 5198 8 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective ATR kinase inhibitor; antitumor

化学名： 4-[4-[(3R)-3-Methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-1H-indole

纯度： ≥98% (HPLC)

说明书

引用文献 (8)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for AZ 20

AZ 20 is a potent and selective ATR kinase inhibitor (IC₅₀ = 5 nM). Exhibits 7.6-fold selectivity over mTOR and selectivity over a panel of 442 kinases, including ATM kinase, PI3-K isoforms, and DNA-PK. Inhibits cell growth in cell lines with high baseline levels of replication stress. Displays antitumor effects in vivo.

许可信息

Sold for research purposes under agreement from AstraZeneca

化合物库 for AZ 20

AZ 20 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for AZ 20

分子量	412.51
公式	C₂₁H₂₄N₄O₃S
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1233339-22-4
PubChem ID	46244454
InChI Key	SCGCBAAYLFTIJU-CQSZACIVSA-N
Smiles	CS(C4(CC4)C1=CC(N5[C@H](C)COCC5)=NC(C2=CC=CC3=C2C=CN3)=N1)(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AZ 20

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	20.63	50
	ethanol	4.13	10

制备储备液 for AZ 20

以下数据基于产品分子量 412.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	4.85 mL	24.24 mL	48.48 mL
2.5 mM	0.97 mL	4.85 mL	9.7 mL
5 mM	0.48 mL	2.42 mL	4.85 mL
25 mM	0.1 mL	0.48 mL	0.97 mL

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产品说明书 for AZ 20

分析证书/产品说明书

化学品安全技术说明书

参考文献 for AZ 20

参考文献是支持产品生物活性的出版物。

Foote et al (2013) Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity. J.Med.Chem. 56 2125 PMID: 23394205

If you know of a relevant reference for AZ 20, please let us know.

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查看全部 ATM and ATR Kinase Inhibitors

关键词: AZ 20, AZ 20 supplier, AZ20, potent, selective, ATR, Kinase, inhibitors, inhibits, ataxia, telangiectasia, Rad3, related, antitumor, antitumour, replication, stress, ATM, &, Checkpoint, Control, Kinases, 5198, Tocris Bioscience

8 篇 AZ 20 的引用文献

引用文献是使用了 Tocris 产品的出版物。 AZ 20 的部分引用包括：

Teloni et al (2019) Efficient Pre-mRNA Cleavage Prevents Replication-Stress-Associated Genome Instability. Mol Cell 73 670 PMID: 30639241

Kilic et al (2019) Phase separation of 53BP1 determines liquid-like behavior of DNA repair compartments. EMBO J e101379 PMID: 31267591

George et al (2021) MYBL2 and ATM suppress replication stress in pluripotent stem cells. EMBO Rep 22 e51120 PMID: 33779025

Daniel et al (2022) Etoposide-induced DNA damage is increased in p53 mutants: identification of ATR and other genes that influence effects of p53 mutations on Top2-induced cytotoxicity. Oncotarget 13 332-346 PMID: 35178190

Stephen P et al (2019) A Compendium of Mutational Signatures of Environmental Agents. Cell 177 821-836.e16 PMID: 30982602

Bowry et al (2018) BET Inhibition Induces HEXIM1- and RAD51-Dependent Conflicts between Transcription and Replication. Cell Rep 25 2061 PMID: 30463005

Jiri et al (2020) ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration. Nat Commun 11 4828 PMID: 32973141

Skau et al (2016) FMN2 Makes Perinuclear Actin to Protect Nuclei during Confined Migration and Promote Metastasis. Cell 167 1571 PMID: 27839864

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AZ 20 的评论

平均评分: 5 (Based on 1 Review.)

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Highly stable.

By Anonymous on 06/22/2020

分析类型： In Vitro

种属： Human

细胞系/组织： U2OS

AZ20 (2.4 μM)

I used short treatments with AZ20 in the presence of JQ1.

PMID: 30463005

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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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