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AZD 5363

Cat. No. 6978 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent pan-AKT inhibitor
别名： Capivasertib
化学名： 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AZD 5363

AZD 5363 is a potent pan-AKT inhibitor (IC50 values are 3, 7 and 7 nM for AKt 1, 2 and 3, respectively). Also inhibits P70S6K, PKA, ROCK2 and ROCK1 (IC50 values are 6, 7, 60 and 470 nM, respectively). Inhibits growth of tumor cell lines in vitro, particularly breast, endometrial, gastric, hematologic and prostate cancers. Inhibits growth of human tumor xenografts in mice. Enhances in vivo antitumor effects of Docetaxel (Cat. No. 4056) and Lapatinib (Cat. No. 6811). Orally bioavailable.

化合物库 for AZD 5363

AZD 5363 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for AZD 5363

分子量 428.92
公式 C21H25ClN6O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1143532-39-1
PubChem ID 25227436
InChI Key JDUBGYFRJFOXQC-KRWDZBQOSA-N
Smiles NC1(CCN(CC1)C1=C2C=CNC2=NC=N1)C(=O)N[C@@H](CCO)C1=CC=C(Cl)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AZD 5363

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 42.89 100

制备储备液 for AZD 5363

以下数据基于产品分子量 428.92。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.66 mL 23.31 mL
5 mM 0.47 mL 2.33 mL 4.66 mL
10 mM 0.23 mL 1.17 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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参考文献 for AZD 5363

参考文献是支持产品生物活性的出版物。

Davies et al (2012) Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background. Mol.Cancer Ther. 11 873 PMID: 22294718

If you know of a relevant reference for AZD 5363, please let us know.

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关键词: AZD 5363, AZD 5363 supplier, AZD5363, pan, AKT, inhibitors, inhibits, potent, orally, bioavailable, protein, kinase, B, PKB, Capivasertib, Akt, (Protein, Kinase, B), 6978, Tocris Bioscience

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Pathways for AZD 5363

Akt Signaling Pathway

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.