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AZD 6482

Cat. No. 4839 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective PI 3-Kβ inhibitor
化学名： (-)-2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid
纯度： ≥98%
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AZD 6482

AZD 6482 is a potent and selective inhibitor of PI 3-kinase β (PI 3-Kβ) (IC50 values are 0.69, 13.6, 47.8 and 136 nM for PI 3-Kβ, PI 3-Kδ, PI 3-Kγ and PI 3-Kα, respectively). Selectively inhibits in vivo growth of the PTEN-deficient tumor xenografts HCC70 and PC3. Also exhibits antithrombotic activity.

许可信息

Sold with the permission of AstraZeneca UK Ltd.

化合物库 for AZD 6482

AZD 6482 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for AZD 6482

分子量 408.45
公式 C22H24N4O4
储存 Store at -20°C
纯度 ≥98%
CAS Number 1173900-33-8
PubChem ID 44137675
InChI Key IRTDIKMSKMREGO-OAHLLOKOSA-N
Smiles OC(C1=C(N[C@@H](C2=CC(C)=CN3C2=NC(N4CCOCC4)=CC3=O)C)C=CC=C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AZD 6482

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 40.84 100
1eq. HCl 4.08 10

制备储备液 for AZD 6482

以下数据基于产品分子量 408.45。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.45 mL 12.24 mL 24.48 mL
5 mM 0.49 mL 2.45 mL 4.9 mL
10 mM 0.24 mL 1.22 mL 2.45 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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参考文献 for AZD 6482

参考文献是支持产品生物活性的出版物。

Nylander et al (2012) Human target validation of phosphoinositide 3-kinase (PI3K)β: effects on platelets and Ins sensitivity, using AZD6482 a novel PI3Kβ inhibitor. J.Thromb.Haemost. 10 2127 PMID: 22906130

Ni et al (2012) Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent. Cancer Discov. 2 425 PMID: 22588880

If you know of a relevant reference for AZD 6482, please let us know.

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关键词: AZD 6482, AZD 6482 supplier, AZD6482, PI, 3-kinase, PI3Kβ, inhibitors, inhibits, selective, potent, antitumor, antitumour, antithrombotics, 3-Kinase, Inositol, Lipids, 4839, Tocris Bioscience

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