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BAG 956

Cat. No. 3606 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Dual PI 3-kinase and PDPK1 (PDK1) inhibitor
化学名： α,α,-Dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-benzeneacetonitrile
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BAG 956

BAG 956 is a dual PDPK1 (PDK1) and class I PI 3-K inhibitor (IC50 values are 245, 56, 446, 35 and 117 nM for PDPK1 and PI 3-K p110 -α, -β, -δ, and -γ respectively). Inhibits cellular AKT phosphorylation at Thr308. Blocks cell proliferation, causing arrest in G1 phase of the cell cycle. Slows tumor progression in mouse xenograft models.

化合物库 for BAG 956

BAG 956 is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for BAG 956

分子量 427.5
公式 C28H21N5
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 853910-02-8
PubChem ID 24882589
InChI Key GVPAGJWVBUZHNQ-UHFFFAOYSA-N
Smiles CC3=NC1=C(N3C4=CC=C(C(C)(C#N)C)C=C4)C2=C(C=CC(C#CC5=CN=CC=C5)=C2)N=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BAG 956

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 17.1 40
ethanol 8.55 20

制备储备液 for BAG 956

以下数据基于产品分子量 427.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.4 mM 5.85 mL 29.24 mL 58.48 mL
2 mM 1.17 mL 5.85 mL 11.7 mL
4 mM 0.58 mL 2.92 mL 5.85 mL
20 mM 0.12 mL 0.58 mL 1.17 mL

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参考文献 for BAG 956

参考文献是支持产品生物活性的出版物。

Stauffer et al (2008) Imidazo[4,5-c]quinolines as inhibitors of the PI3K/PKB-pathway. Bioorg.Med.Chem.Lett. 18 1027 PMID: 18248814

Weisberg et al (2008) Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells. Blood 111 3723 PMID: 18184863

Marone et al (2009) Targeting melanoma with dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors. Mol.Cancer Res. 7 601 PMID: 19372588

If you know of a relevant reference for BAG 956, please let us know.

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关键词: BAG 956, BAG 956 supplier, Dual, inhibitors, PDK, PDK1, PI3K, p110, inhibits, PI, 3-kinases, Signaling, Signalling, Phosphoinositide, Kinases, PIP2, Inositol, Lipids, cAMP, 3-phosphoinositide, dependent, protein, kinase-1, BAG956, PDPK1, 3-Kinase, Phosphoinositide-dependent, Kinase, 1, 3606, Tocris Bioscience

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