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Bax channel blocker

Cat. No. 2160 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Allosteric inhibitor of Bax channel activation
别名： BAI1
化学名： 3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
文献 (2)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Bax channel blocker

Bax channel blocker is a allosteric inhibitor of Bax channel activation. Binds inactive Bax at allosteric site and inhibits tBID-mediated Bax activation (IC50 = 3.3 μM). Selectively inhibits Bax-dependent apoptosis. Potent inhibitor of Bax-mediated mitochondrial cytochrome c release (IC50 = 0.52 μM).

化合物库 for Bax channel blocker

Bax channel blocker is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Bax channel blocker

分子量 540.12
公式 C19H21Br2N3O.2HCl
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 329349-20-4
PubChem ID 2729026
InChI Key HWFKCAFKXZFOQT-UHFFFAOYSA-N
Smiles Cl.Cl.OC(CN1C2=C(C=C(Br)C=C2)C2=C1C=CC(Br)=C2)CN1CCNCC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Bax channel blocker

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 2.34 5
DMSO 46.72 100

制备储备液 for Bax channel blocker

以下数据基于产品分子量 540.12。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.85 mL 9.26 mL 18.51 mL
5 mM 0.37 mL 1.85 mL 3.7 mL
10 mM 0.19 mL 0.93 mL 1.85 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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产品说明书 for Bax channel blocker

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Bax channel blocker

参考文献是支持产品生物活性的出版物。

Bombrun et al (2003) 3,6-Dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation. J.Med.Chem. 46 21

Garner et al (2019) Small-molecule allosteric inhibitors of BAX. Nat.Chem.Biol. 15 322 PMID: 30718816

If you know of a relevant reference for Bax channel blocker, please let us know.

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关键词: Bax channel blocker, Bax channel blocker supplier, inhibitors, inhibits, Bax-mediated, mitochondrial, cytochrome, c, release, Bcl-2, Family, allosteric, activation, BAI1, 2160, Tocris Bioscience

2 篇 Bax channel blocker 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Bax channel blocker 的部分引用包括：

Ono et al (2017) Feedback activation of AMPK-mediated autophagy acceleration is a key resistance mechanism against SCD1 inhibitor-induced cell growth inhibition. PLoS One 12 e0181243 PMID: 28704514

Sano et al (2016) Vacuolin-1 inhibits autophagy by impairing lysosomal maturation via PIKfyve inhibition. FEBS Lett 590 1576 PMID: 27135648

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