Bay 11-7821

Cat. No. 1744 8 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： E2 ubiquitin (Ub) conjugating enzymes inhibitor

别名： Bay 11-7082

化学名： (2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile

纯度： ≥99% (HPLC)

引用文献 (8)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Bay 11-7821

Bay 11-7821 is an E2 ubiquitin (Ub) conjugating enzyme inhibitor. Inhibits the conjugation of Ub to a range of E2 enzymes. Inhibits E2 enzyme mediated IκBα phosphorylation and indirectly decreases NF-κb activity. Also reversibly activates MAPK signaling. Induces apoptosis of leukemic T cell and B-cell lymphoma cell lines. Also inhibits activation of NLRP3 inflammasome. Binds and inhibits gasdermin D (GSDMD) pore formation. Pyroptosis inhibitor.

技术数据 for Bay 11-7821

分子量	207.25
公式	C₁₀H₉NO₂S
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	19542-67-7
PubChem ID	5353431
InChI Key	DOEWDSDBFRHVAP-KRXBUXKQSA-N
Smiles	CC1=CC=C(C=C1)S(=O)(=O)\C=C\C#N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Bay 11-7821

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	ethanol	5.18	25
	DMSO	20.73	100

制备储备液 for Bay 11-7821

以下数据基于产品分子量 207.25。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	4.83 mL	24.13 mL	48.25 mL
5 mM	0.97 mL	4.83 mL	9.65 mL
10 mM	0.48 mL	2.41 mL	4.83 mL
50 mM	0.1 mL	0.48 mL	0.97 mL

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产品说明书 for Bay 11-7821

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Bay 11-7821

参考文献是支持产品生物活性的出版物。

Mori et al (2002) Bay 11-7082 inhibits transcription factor NF-κB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells. Blood 100 1828 PMID: 12176906

Pierce et al (1997) Novel inhibitors of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J.Biol.Chem. 272 21096 PMID: 9261113

Strickson et al (2013) The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system. Biochem.J. 451 427 PMID: 23441730

Juliana et al (2010) Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome. J.Biol.Chem. 285 9792 PMID: 20093358

Pandeya et al (2019) Gasdermin D (GSDMD) as a new target for the treatment of infection. Medchemcomm 10 660 PMID: 31191857

If you know of a relevant reference for Bay 11-7821, please let us know.

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