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BI 605906

Cat. No. 5300 3 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

This product has been withdrawn from sale and is superseded by TPCA-1 (Cat. No. 2559)
说明： Selective IKKβ inhibitor
化学名： 3-Amino-4-(1,1-difluoropropyl)-6-[4-(methylsulfonyl)-1-piperidinyl]thieno[2,3-b]pyridine-2-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for BI 605906

BI 605906 is a selective IKKβ inhibitor (IC50 = 380 nM). Displays no effect on a panel of 100 kinases, except at IGF1 (IC50 = 7.6 μM).

External Portal Information for BI 605906

The Chemical Probes webpages of the Structural Genomics Consortium are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BI 605906 is reviewed on the chemical probes website.

化合物库 for BI 605906

BI 605906 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for BI 605906

分子量 432.51
公式 C17H22F2N4O3S2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 960293-88-3
PubChem ID 23652660
InChI Key IYHHRZBKXXKDDY-UHFFFAOYSA-N
Smiles CS(C(CC3)CCN3C1=CC(C(CC)(F)F)=C(C(N)=C(C(N)=O)S2)C2=N1)(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for BI 605906

参考文献是支持产品生物活性的出版物。

Clark et al (2011) Novel cross-talk within the IKK family controls innate immunity. Biochem.J. 434 93 PMID: 21138416

Zhang et al (2014) An unexpected twist to the activation of IKKβ: TAK1 primes IKK beta for activation by autophosphorylation. Biochem.J. 461 531 PMID: 24911653

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关键词: BI 605906, BI 605906 supplier, BI605906, ikk-2, NF-kappaB, NF-kB, IkappaB, Kinases, Nuclear, Factor, Kappa, B, potent, selective, inhibitors, inhibits, inhibitory, factor-kappab, ab, kinases, NF-κβ, IkB, Kinase, NF-kB/IkB, 5300, Tocris Bioscience

3 篇 BI 605906 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BI 605906 的部分引用包括：

Derek A et al (2023) Impact of retrotransposon protein L1 ORF1p expression on oncogenic pathways in hepatocellular carcinoma: the role of cytoplasmic PIN1 upregulation. Br J Cancer 128 1236-1248 PMID: 36707636

Diti et al (2021) Syntaxin 4 Mediates NF-κB Signaling and Chemokine Ligand Expression via Specific Interaction With IκBβ. Diabetes 70 889-902 PMID: 33526588

Mina J et al (2022) The PI3K/mTOR inhibitor Gedatolisib eliminates dormant breast cancer cells in organotypic culture, but fails to prevent metastasis in preclinical settings. Mol Oncol 16 130-147 PMID: 34058066

BI 605906 的评论

平均评分: 5 (Based on 1 Review.)

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BI 605906 protects macrophages against LPS-induced inflammation.
By Anonymous on 12/11/2018
分析类型： In Vitro
种属： Mouse
细胞系/组织： Macrophages

RAW macrophages were incubated with 5 μM BI 605906 for 30 min prior to addition of 200 ng/ml LPS for 8 h to follow TNFa mRNA expression. LPS elevated TNFa mRNA levels that was significantly inhibited by pretreatment of cells with BI 605906.

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