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BMS 345541

Cat. No. 4806 2 篇引用文献 2 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective allosteric inhibitor of IKK; anti-inflammatory
化学名： N1-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine hydrochloride
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BMS 345541

BMS 345541 is a selective allosteric inhibitor of IKK (IC50 values are 0.3 and 4.0 μM for IKKβ and IKKα respectively). Exhibits no effect against a panel of 15 other kinases. Attenuates LPS-induced cytokine production in vitro and blocks NFκB dependent transcription in mice. Also suppresses joint destruction in a mouse model of arthritis.

化合物库 for BMS 345541

BMS 345541 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for BMS 345541

分子量 291.78
公式 C14H17N5.HCl
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 547757-23-3
PubChem ID 9926054
InChI Key MIDKPVLYXNLFGZ-UHFFFAOYSA-N
Smiles NCCNC1=NC3=C(C=C(C)C=C3)N2C1=NC=C2C.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BMS 345541

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 29.18 100
DMSO 29.18 100

制备储备液 for BMS 345541

以下数据基于产品分子量 291.78。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.43 mL 17.14 mL 34.27 mL
5 mM 0.69 mL 3.43 mL 6.85 mL
10 mM 0.34 mL 1.71 mL 3.43 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

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参考文献 for BMS 345541

参考文献是支持产品生物活性的出版物。

Pattoli et al (2005) Collagen and aggrecan degradation is blocked in interleukin-1-treated cartilage explants by an inhibitor of IκB kinase through suppression of metalloproteinase expression. J.Pharmacol.Exp.Ther. 315 382 PMID: 16009742

Burke et al (2003) BMS-345541 is a highly selective inhibitor of IκB kinase that binds at an allosteric site of the enzyme and blocks NF- κB-dependent transcription in mice. J.Biol.Chem. 278 1450 PMID: 12403772

De Silva et al (2010) Inhibition of choriodecidual cytokine production and inflammatory gene expression by selective IκB kinase (IKK) inhibitors. Br.J.Pharmacol. 160 1808 PMID: 20649582

If you know of a relevant reference for BMS 345541, please let us know.

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关键词: BMS 345541, BMS 345541 supplier, BMS345541, Selective, IKK, allosteric, inhibitors, inhibits, anti-inflammatory, IKKβ, IKKμ, arthritis, IKK1, IKK2, IkB, Kinase, NF-kB/IkB, 4806, Tocris Bioscience

2 篇 BMS 345541 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BMS 345541 的部分引用包括：

Reho et al (2019) Mechanistic Target of Rapamycin Complex 1 Signaling Modulates Vascular Endothelial Function Through Reactive Oxygen Species. J Am Heart Assoc 8 e010662 PMID: 31020916

Michael et al (2019) Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING. Mol Cell 74 801-815.e6 PMID: 30952515

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BMS 345541 的评论

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BMS 345541 (Cat. No. 4806) in 3 D cultures.
By Clara Lubeseder-Martellato on 11/12/2021
分析类型： Ex Vivo
种属： Mouse
细胞系/组织： Acini

BMS 345541 was added to pancreatic acinar 3-dimensional cultures and differentiation of the cultures was monitored for 3 to 4 days. The concentration ranged between 1 and 10 uM.

Great, easy to store.
By Brian Englar on 02/06/2019
分析类型： Ex Vivo
种属： Human
细胞系/组织： MDA-231

This IKK inhibitor worked in our evaluation of TAK1 in MDA-231 cells. We compared the ability of this inhibitor to induce TNf mediated death to a TAK1 inhibitor.

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