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Submit ReviewBryostatin 2
Discontinued Product
This product has been withdrawn from sale and is superseded by Bryostatin 1 (Cat. No. 2383)
说明： Protein kinase C activator
化学名： (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-1,11,21,25-Tetrahydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl-(2E,4E)-2,4-octadienoic acid ester
纯度： ≥98%
生物活性 for Bryostatin 2
Protein kinase C (PKC) activator; analog of Bryostatin 1 (Cat. No. 2383). Attenuates cell proliferation and cell attachment in U937 cells. Inhibits DNA synthesis at 100 nM in SH-SY5Y human neuroblastoma cells. Also inhibits EGF binding and induces arachidonic acid release in vitro. Antitumor.
技术数据 for Bryostatin 2
| 分子量 | 863 |
| 公式 | C45H66O16 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% |
| CAS Number | 87745-28-6 |
| PubChem ID | 6438131 |
| InChI Key | LIPGUSBNMQRYNL-IZBIBDMISA-N |
| Smiles | O[C@H](C(C)2C)C[C@@H](C[C@@H](O)CC(O[C@@H]([C@H](O)C)C[C@@H](O4)C3)=O)O[C@@]2(O)C[C@H](C1)O[C@@H](/C=C/C(C)(C)[C@@]4(O)[C@@H](OC(/C=C/C=C/CCC)=O)/C3=C/C(OC)=O)C/C1=C\C(OC)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Bryostatin 2
参考文献 for Bryostatin 2
参考文献是支持产品生物活性的出版物。
Dale et al (1989) Comparison of effects of bryoSTAT 1 and 2 and 12-O-tetradecanoylphorbol-13-acetate on protein kinase C activity in A549 human lung carcinoma cells. Cancer Res. 49 3242 PMID: 2720677
Dell'Aquila et al (1988) Differential effects of bryoSTAT and phorbol esters on arachidonic acid metabolite release and epidermal growth factor binding in C3H 10T1/2 cells. Cancer Res. 48 3702 PMID: 3132318
Jalava et al (1990) Effects of bryoSTAT 1 and 2 on morphological and functional differentiation of SH-SY5Y human neuroblastoma cells. Cancer Res. 50 3422 PMID: 2334938
Kedei et al (2013) Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action. Biochem Pharmacol. 85 313 PMID: 23146662
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关键词: Bryostatin 2, Bryostatin 2 supplier, Protein, Kinase, C, PKC, activators, analogue, Bryostatin, 1, antitumor, macrocyclic, lactone, arachidonic, acid, release, 5237, Tocris Bioscience
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