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C25-140

Cat. No. 7715 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： TRAF6-Ubc13 interaction inhibitor
化学名： 3-[3,5-Dimethyl-1-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazol-4-yl]-1-[4-(phenylmethyl)-1-piperidinyl]-1-propanone
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for C25-140

C25-140 binds directly to TNF receptor-associated factor 6 (TRAF6) and inhibits its interaction with ubiquitin-conjugating enzyme Ubc13. C25-140 reduces TRAF6-Ubc13 activity and decreases NF-κB activation and inflammatory signaling in vitro. C25-140 exhibits selectivity for TRAF6 over other E3 ligases except cIAP1. In in vivo mouse models of autoimmune psoriasis and rheumatoid arthritis, the compound improves disease symptoms. The compound also suppresses the pro-inflammatory signaling activity of IL-17A and prevents its inhibitory effect on the anti-HBV action of IFN-α HepG2 cells.

技术数据 for C25-140

分子量 457.57
公式 C26H31N7O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1358099-18-9
PubChem ID 53093165
InChI Key HFKVRXVHZGBRKF-UHFFFAOYSA-N
Smiles O=C(N1CCC(CC=2C=CC=CC2)CC1)CCC=3C(=NN(C4=NN5C(=NN=C5C)C=C4)C3C)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for C25-140

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 22.88 50
ethanol 4.58 10

制备储备液 for C25-140

以下数据基于产品分子量 457.57。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.37 mL 21.85 mL 43.71 mL
2.5 mM 0.87 mL 4.37 mL 8.74 mL
5 mM 0.44 mL 2.19 mL 4.37 mL
25 mM 0.09 mL 0.44 mL 0.87 mL

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参考文献 for C25-140

参考文献是支持产品生物活性的出版物。

Brenke et al (2018) Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity. J.Biol.Chem. 293 13191 PMID: 29950522

Zhang et al (2022) Interleukin-17A pretreatment attenuates the anti-hepatitis B virus efficacy of interferon-alpha by reducing activation of the interferon-stimulated gene factor 3 transcriptional complex in hepatitis B virus-expressing HepG2 cells. Virol.J. 19 28 PMID: 35144643

If you know of a relevant reference for C25-140, please let us know.

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关键词: C25-140, C25-140 supplier, inhibits, inhibitors, TRAF6-Ubc13, NF-kB, NF-KappaB, κ, E3, ligases, Ubiquitin, Ligases, NF-kB/IkB, 7715, Tocris Bioscience

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