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CBR-470-1

Cat. No. 7018 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： PGK1 inhibitor; activates Nrf2
化学名： (3R,4S)-rel-4-[(4-Chlorophenyl)sulfonyl]tetrahydro-N-(2-methylpropyl)-3-thiophenamine-1,1-dioxide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CBR-470-1

CBR-470-1 is a phosphoglycerate kinase 1 (PGK1) inhibitor. CBR-470-1 promotes accumulation of the reactive metabolites methylglyoxal (MGO) resulting in KEAP1 modification and dimerization, which in turn leads to activation of the Nrf2 transcriptional program. CBR-470-1 protects SH-SY5Y neuroblastoma cells from MPP+-induced cytotoxicity via the Keap1-Nrf2 cascade.

化合物库 for CBR-470-1

CBR-470-1 is also offered as part of the Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for CBR-470-1

分子量 365.89
公式 C14H20ClNO4S2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2416095-06-0
PubChem ID 20898025
InChI Key NFEQFEDSWINARK-KBPBESRZSA-N
Smiles CC(CN[C@H]1CS(=O)(C[C@@H]1S(=O)(C2=CC=C(C=C2)Cl)=O)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CBR-470-1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 36.59 100
ethanol 7.32 20

制备储备液 for CBR-470-1

以下数据基于产品分子量 365.89。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.73 mL 13.67 mL 27.33 mL
5 mM 0.55 mL 2.73 mL 5.47 mL
10 mM 0.27 mL 1.37 mL 2.73 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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参考文献 for CBR-470-1

参考文献是支持产品生物活性的出版物。

Bollong et al (2018) A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. Nature 562 600 PMID: 30323285

Zheng et al (2020) PGK1 inhibitor CBR-470-1 protects neuronal cells from MPP+. Aging (Albany NY) 12 13388 PMID: 32649311

If you know of a relevant reference for CBR-470-1, please let us know.

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关键词: CBR-470-1, CBR-470-1 supplier, phosphoglycerate, kinase, 1, (PGK1), inhibitor, cytoprotection, NRF2, activator, KEAP1, Other, Kinases, Nrf2, 7018, Tocris Bioscience

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