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CGP 53353

Cat. No. 2442 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective inhibitor of PKCβII
化学名： 5,6-bis[(4-Fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione
纯度： ≥99% (HPLC)
说明书
引用文献 (3)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CGP 53353

CGP 53353 is a selective inhibitor of PKCβII (IC50 values are 0.41 and 3.8 μM for PKCβII and PKCβI respectively). Also inhibits prionogenic Sup35 fibrillization (IC50 ~ 3.4 μM) and inhibits de novo Aβ42 assembly in vitro.

化合物库 for CGP 53353

CGP 53353 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for CGP 53353

分子量 365.34
公式 C20H13F2N3O2
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 145915-60-2
PubChem ID 6711154
InChI Key RONQPWQYDRPRGG-UHFFFAOYSA-N
Smiles FC1=CC=C(NC2=CC3=C(C=C2NC2=CC=C(F)C=C2)C(=O)NC3=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CGP 53353

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 36.53 100
ethanol 7.31 20

制备储备液 for CGP 53353

以下数据基于产品分子量 365.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.69 mL 27.37 mL
5 mM 0.55 mL 2.74 mL 5.47 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for CGP 53353

参考文献是支持产品生物活性的出版物。

Kouroedov et al (2004) Selective inhibition of protein kinase Cβ2 prevents acute effects of high glucose on vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation 110 91 PMID: 15210597

Wang et al (2008) Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proc.Natl.Acad.Sci.USA 105 7159

If you know of a relevant reference for CGP 53353, please let us know.

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关键词: CGP 53353, CGP 53353 supplier, Selective, inhibitors, inhibits, PKCbetaII, de, novo, Aβ4, β42, beta42, assesmbly, PKC, PKM, Protein, Kinase, C, Kinases, b-amyloid, β-Amyloid, beta-Amyloid, Precursor, APP, Secretase, beta, Peptides, prionogenic, Sup35, fibrillization, CGP53353, amyloidbeta, amyloidb, Amyloid, Beta, 2442, Tocris Bioscience

3 篇 CGP 53353 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CGP 53353 的部分引用包括：

Liu et al (2014) PKCβII acts downstream of chemoattractant receptors and mTORC2 to regulate cAMP production and myosin II activity in neutrophils. Mol Biol Cell 25 1446 PMID: 24600048

He et al (2011) Stanniocalcin-1 promotes tumor angiogenesis through up-regulation of VEGF in gastric cancer cells. J Neurosci 18 39 PMID: 21672207

Ramana et al (2007) Aldose reductase-regulated tumor necrosis factor-α production is essential for high glucose-induced vascular smooth muscle cell growth. Endocrinology 148 4371 PMID: 17584970

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