CHIR 99021 trihydrochloride

Cat. No. 4953 19 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Hydrochloride salt of CHIR 99021 (Cat. No. 4423); selective GSK-3 inhibitor

别名： CT99021

化学名： 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile trihydrochloride

纯度： ≥98% (HPLC)

引用文献 (19)

文献 (4)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CHIR 99021 trihydrochloride

CHIR 99021 trihydrochloride is a hydrochloride salt of CHIR 99021 (Cat. No. 4423), a highly selective GSK-3 inhibitor.

CHIR 99021, CHIR 99021 in solution and CHIR 99021 synthesized to cGMP guidelines also available.

External Portal Information for CHIR 99021 trihydrochloride

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CHIR 99021 is reviewed on the chemical probes website.

技术数据 for CHIR 99021 trihydrochloride

分子量	574.72
公式	C₂₂H₁₈Cl₂N₈.3HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1782235-14-6
PubChem ID	78243722
InChI Key	DSFVSCNMMZRCIA-UHFFFAOYSA-N
Smiles	ClC(C=C3Cl)=CC=C3C1=NC(NCCNC4=CC=C(C#N)C=N4)=NC=C1C2=NC(C)=CN2.Cl.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CHIR 99021 trihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	14.37	25
	DMSO	28.74	50

制备储备液 for CHIR 99021 trihydrochloride

以下数据基于产品分子量 574.72。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	3.48 mL	17.4 mL	34.8 mL
2.5 mM	0.7 mL	3.48 mL	6.96 mL
5 mM	0.35 mL	1.74 mL	3.48 mL
25 mM	0.07 mL	0.35 mL	0.7 mL

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产品说明书 for CHIR 99021 trihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CHIR 99021 trihydrochloride

参考文献是支持产品生物活性的出版物。

Pan et al (2011) AKT kinase activity is required for Li to modulate mood-related behaviors in mice. Neuropsychopharmacology 36 1397 PMID: 21389981

Ring et al (2003) Selective glycogen synthase kinase 3 inhibitors potentiate Ins activation of glucose transport and utilization in vitro and in vivo. Diabetes 52 588 PMID: 12606497

Ye et al (2012) Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embyronic stem cells from refractory mouse strains. PLoS One 7 e35892 PMID: 22540008

If you know of a relevant reference for CHIR 99021 trihydrochloride, please let us know.

按标靶查看相关产品

关键词: CHIR 99021 trihydrochloride, CHIR 99021 trihydrochloride supplier, CHIR99021, trihydrochloride, glycogen, synthase, kinase, 3, gsk-3, gsk-3a, gsk-3alpha, gsk-3α, gsk-3b, gsk-3beta, gsk-3β, inhibitors, inhibits, highly, selective, potent, CT99021, Glycogen, Synthase, Kinase, 4953, Tocris Bioscience

19 篇 CHIR 99021 trihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CHIR 99021 trihydrochloride 的部分引用包括：

Yoav et al (2020) Systematic Comparison of High-throughput Single-Cell and Single-Nucleus Transcriptomes during Cardiomyocyte Differentiation. Sci Rep 10 1535 PMID: 32001747

Johannes et al (2020) Deep Characterization of Circular RNAs from Human Cardiovascular Cell Models and Cardiac Tissue. Cells 9 PMID: 32635460

Michael et al (2020) iPSC Modeling of RBM20-Deficient DCM Identifies Upregulation of RBM20 as a Therapeutic Strategy. Cell Rep 32 108117 PMID: 32905764

Wei et al (2023) Generation and characterization of NGLY1 patient-derived midbrain organoids. Front Cell Dev Biol 11 1039182 PMID: 36875753

Yasuhiro et al (2023) Self-organized yolk sac-like organoids allow for scalable generation of multipotent hematopoietic progenitor cells from induced pluripotent stem cells. Cell Rep Methods 3 100460 PMID: 37159663

Montefiori et al (2018) A promoter interaction map for cardiovascular disease genetics. Elife 7 PMID: 29988018

Peter et al (2021) Non-invasive and high-throughput interrogation of exon-specific isoform expression. Nat Cell Biol 23 652-663 PMID: 34083785

David E et al (2021) Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions. Elife 10 PMID: 33988505

Matthew et al (2021) Dynamic effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes. Elife 10 PMID: 33554857

Ling et al (2021) Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids. Cell Stem Cell 28 1090-1104.e6 PMID: 33915081

Viktoriya et al (2021) Autologous transplant therapy alleviates motor and depressive behaviors in parkinsonian monkeys. Nat Med 27 632-639 PMID: 33649496

Benjamin et al (2021) Single-molecule, full-length transcript isoform sequencing reveals disease-associated RNA isoforms in cardiomyocytes. Nat Commun 12 4203 PMID: 34244519

Modic et al (2019) Cross-Regulation between TDP-43 and Paraspeckles Promotes Pluripotency-Differentiation Transition. Mol Cell 74 951 PMID: 31047794

Ward and Gilad (2019) A generally conserved response to hypoxia in iPSC-derived cardiomyocytes from humans and chimpanzees. Elife 8 PMID: 30958265

Guanghao et al (2022) Single-cell sequencing reveals lineage-specific dynamic genetic regulation of gene expression during human cardiomyocyte differentiation. PLoS Genet 18 e1009666 PMID: 35061661

Kate G et al (2022) Human spinal cord in vitro differentiation pace is initially maintained in heterologous embryonic environments. Elife 11 PMID: 35188104

Dmitry et al (2022) Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction. Sci Rep 12 3100 PMID: 35260583

Jia et al (2022) Selective activation and down-regulation of Trk receptors by neurotrophins in human neurons co-expressing TrkB and TrkC. J Neurochem 161 463-477 PMID: 35536742

Judson et al (2018) Inhibition of methyltransferase Setd7 allows in vitro expansion of myogenic stem cells with improved therapetic potential. Cell Stem Cell 22 177 PMID: 29395054

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