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Submit ReviewCholesterol
说明： Component of lipid nanoparticles (LNPs); modulator of lipid bilayer fluidity
化学名： (3β)-Cholest-5-en-3-ol
纯度： ≥95% (HPLC)
生物活性 for Cholesterol
Cholesterol is a major sterol in all mammalian organisms; it is an essential component that makes up about 20-25% of the structural lipids of cell membranes. Cholesterol determines the permeability and fluidity characteristics of the cell membranes. Cholesterol is an endogenous ligand for estrogen-related receptor α (ERRα). It is also a precursor in several biosynthetic pathways, including steroid hormones and the active form of vitamin D. Cholesterol is a component of lipid nanoparticles (LNPs), and is important in modulating membrane stability, with the effect being context dependent. When combined with lipids that have low gel-liquid crystalline phase transition temperature (Tm), Cholesterol reduces membrane fluidity and increases bilayer thickness; when combined with high Tm lipids, it increases membrane fluidity and narrows the bilayer thickness.
For more information on how to prepare MC3 lipid nanoparticles for RNA delivery, please see our protocol.
技术数据 for Cholesterol
| 分子量 | 386.65 |
| 公式 | C27H46O |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 57-88-5 |
| PubChem ID | 5997 |
| InChI Key | HVYWMOMLDIMFJA-DPAQBDIFSA-N |
| Smiles | C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(=CC3)C[C@@H](O)CC4)(CC1)[H])[H])(CC[C@@]2([C@@H](CCCC(C)C)C)[H])[H] |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Cholesterol
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| ethanol | 19.33 | 50 温和加热 | |
| chloroform | 38.66 | 100 |
制备储备液 for Cholesterol
以下数据基于产品分子量 386.65。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.59 mL | 12.93 mL | 25.86 mL |
| 5 mM | 0.52 mL | 2.59 mL | 5.17 mL |
| 10 mM | 0.26 mL | 1.29 mL | 2.59 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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产品说明书 for Cholesterol
参考文献 for Cholesterol
参考文献是支持产品生物活性的出版物。
Tenchov et al (2021) Lipid nanoparticles - from liposomes to mRNA vaccine delivery, a landscape of research diversity and advancement. ACS Nano 15 16982 PMID: 34181394
Cheng et al (2018) Dendrimer-based lipid nanoparticles deliver therapeutic fah mRNA to normalize liver function and extend survival in a mouse model of hepatorenal tyrosinemia type I. Adv.Mater 30 e1805308 PMID: 30368954
Ghanbari et al (2020) Cholesterol as an endogenous ligand of ERRα promotes ERRα-mediated cellular proliferation and metabolic target gene expression in breast cancer cells. Cell 9 1765 PMID: 32717915
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关键词: Cholesterol, Cholesterol supplier, Cholesterol, structural, lipid, membrane, fluidity, nanoparticle, LNP, estrogen-related, receptor, alpha, ERRa, Biochemicals, and, Molecular, Biology, Estrogen, Related, Receptors, Lipid, Nanoparticles, 7945, Tocris Bioscience
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