CKI 7 dihydrochloride

Cat. No. 5329 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： CK1 inhibitor

化学名： N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide dihydrochloride

纯度： ≥99% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CKI 7 dihydrochloride

CKI 7 dihydrochloride is a casein kinase 1 (CK1) inhibitor. Also inhibits SGK, S6K1 and MSK1. Induces retinal cell differentiation from human ESCs and iPSCs in combination with SB 431542 (Cat. No. 1614) and Y-27632 (Cat. No. 1254).

化合物库 for CKI 7 dihydrochloride

CKI 7 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for CKI 7 dihydrochloride

分子量	358.67
公式	C₁₁H₁₂ClN₃O₂S.2HCl
储存	Store at -20°C
纯度	≥99% (HPLC)
CAS Number	1177141-67-1
PubChem ID	16078955
InChI Key	JUAVTXYOCISSSL-UHFFFAOYSA-N
Smiles	ClC2=CC=C(S(NCCN)(=O)=O)C1=CN=CC=C12.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CKI 7 dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	3.59	10
	DMSO	17.93	50

制备储备液 for CKI 7 dihydrochloride

以下数据基于产品分子量 358.67。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	5.58 mL	27.88 mL	55.76 mL
2.5 mM	1.12 mL	5.58 mL	11.15 mL
5 mM	0.56 mL	2.79 mL	5.58 mL
25 mM	0.11 mL	0.56 mL	1.12 mL

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产品说明书 for CKI 7 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CKI 7 dihydrochloride

参考文献是支持产品生物活性的出版物。

Osakada et al (2009) In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J.Cell Sci. 122 3169 PMID: 19671662

Rena et al (2004) D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. EMBO Rep. 5 60 PMID: 14710188

Peifer et al (2009) 3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38α mitogen activated protein kinase and casein kinase 1δ. J.Med.Chem. 52 7618 PMID: 19591487

If you know of a relevant reference for CKI 7 dihydrochloride, please let us know.

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关键词: CKI 7 dihydrochloride, CKI 7 dihydrochloride supplier, CKI7, dihydrochloride, casein, kinases, CK1, stem, cells, retinal, differentiation, ESCs, iPSCs, embryonic, induced, pluripotent, Casein, Kinase, 1, Retinal, Stem, Cells, and, iPSC, 5329, Tocris Bioscience

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