Clofarabine

Discontinued Product

2600 has been discontinued.

View all Other Kinases products.
说明: Deoxycytidine kinase (dCK) substrate
化学名: 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
纯度: ≥99% (HPLC)
说明书
引用文献 (1)
评论

生物活性 for Clofarabine

Clofarabine is a deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-α and -ε and potently inhibits ribonucleotide reductase (IC50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.

化合物库 for Clofarabine

Clofarabine is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Clofarabine

分子量 303.68
公式 C10H11ClFN5O3
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 123318-82-1
PubChem ID 119182
InChI Key WDDPHFBMKLOVOX-AYQXTPAHSA-N
Smiles O[C@@H]1[C@@H](CO)O[C@@H](N(C=N3)C2=C3C(N)=NC(Cl)=N2)[C@H]1F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Clofarabine

分析证书/产品说明书
选择另一批次:

参考文献 for Clofarabine

参考文献是支持产品生物活性的出版物。

Parker et al (1991) Effects of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate. Cancer Res. 51 2386 PMID: 1707752

Bonate et al (2006) Discovery and development of clofarabine: a nucleoside analogue for treating cancer. Nat.Rev.Drug Discov. 5 855 PMID: 17016426

Carson et al (1992) Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine. Proc.Natl.Acad.Sci.USA 89 2970

按产品操作查看相关产品

查看全部 Other Kinase Substrates

关键词: Clofarabine, Clofarabine supplier, Deoxycytidine, kinases, dCK, Enzyme, Substrates, activators, antimetabolites, chemotherapeutics, /, Activators, Other, Kinases, 2600, Tocris Bioscience

1 篇 Clofarabine 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Clofarabine 的部分引用包括:

Xie et al (2012) Valproic acid synergistically enhances the cytotoxicity of clofar. in pediatric acute myeloid leukemia cells. Pediatr Blood Cancer 59 1245 PMID: 22488775


Clofarabine 的评论

目前没有该产品的评论。 Be the first to review Clofarabine and earn rewards!

Have you used Clofarabine?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review