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CP 43

Cat. No. 6558 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent TAOK inhibitor
化学名： N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CP 43

CP 43 is a potent TAO kinase (TAOK) inhibitor (IC50 values are 11 nM/L and 15 nM/L for TAOK1 and TAOK2, respectively). Inhibits TAOK phosphorylation and activation of JNK in vitro. Prolongs duration of mitosis and increases mitotic cell death in the SKBR3 breast cancer cell line. Also reduces tau phopshorylation in cortical neurons at sites associated with neurodegeneration in human tauopathies.

化合物库 for CP 43

CP 43 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for CP 43

分子量 384.47
公式 C25H24N2O2
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 850467-66-2
PubChem ID 46673962
InChI Key WQKXOAJVNFOHNZ-UHFFFAOYSA-N
Smiles O=C(NC1CCCC2=CC=CC=C12)CNC(C3=CC=C(C4=CC=CC=C4)C=C3)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CP 43

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 38.45 100
ethanol 7.69 20

制备储备液 for CP 43

以下数据基于产品分子量 384.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.6 mL 13 mL 26.01 mL
5 mM 0.52 mL 2.6 mL 5.2 mL
10 mM 0.26 mL 1.3 mL 2.6 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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参考文献 for CP 43

参考文献是支持产品生物活性的出版物。

Koo et al (2017) Targeting TAO kinase using a new inhibitor compound delays mitosis and induces mitotic cell death in centrosome amplified breast cancer cells. Mol.Cancer Ther. 16 2410 PMID: 28830982

Giacomini et al (2018) A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies. Acta Neuropathol.Commun. 6 37 PMID: 29730992

If you know of a relevant reference for CP 43, please let us know.

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关键词: CP 43, CP 43 supplier, CP43, TAOK, TAOK1, TAOK2, TAO, thousand, and, one, amino, acid, kinase, inhibitors, inhibits, potent, JNK, activation, Other, Kinases, JNK/c-jun, 6558, Tocris Bioscience

1 篇 CP 43 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CP 43 的部分引用包括：

Smita et al (2021) TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules. Dev Cell 56 3321-3333.e5 PMID: 34879262

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