CRT 0066854 hydrochloride

Cat. No. 5922 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： PKCι and PKCζ inhibitor

化学名： (2S)-3-Phenyl-N¹-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]-1,2-propanediamine dihydrochloride

纯度： ≥95% (HPLC)

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CRT 0066854 hydrochloride

CRT 0066854 hydrochloride is a protein kinase C (PKC) inhibitor. Inhibits PKCι and PKCζ (IC₅₀ values are 132 and 639 nM, respectively). Restores polarized morphogenesis in oncogene expressing MDCK cells, decreases colony formation in HeLa cells and inhibits lethal giant larvae 2 (LLGL2) phosphorylation.

化合物库 for CRT 0066854 hydrochloride

CRT 0066854 hydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for CRT 0066854 hydrochloride

分子量	488.48
公式	C₂₄H₂₅N₅S.2HCl
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	2250019-91-9
PubChem ID	131954580
InChI Key	NYUVOWXZRBZQBA-NTEVMMBTSA-N
Smiles	N[C@@H](CC1=CC=CC=C1)CNC2=C3C4=C(SC3=NC(C5=CC=NC=C5)=N2)CCCC4.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CRT 0066854 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	48.85	100
	DMSO	48.85	100

制备储备液 for CRT 0066854 hydrochloride

以下数据基于产品分子量 488.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.05 mL	10.24 mL	20.47 mL
5 mM	0.41 mL	2.05 mL	4.09 mL
10 mM	0.2 mL	1.02 mL	2.05 mL
50 mM	0.04 mL	0.2 mL	0.41 mL

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产品说明书 for CRT 0066854 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CRT 0066854 hydrochloride

参考文献是支持产品生物活性的出版物。

Linch et al (2014) Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids. Carcinogenesis 35 396 PMID: 24072773

Kjaer et al (2013) Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes. Biochem.J. 451 329 PMID: 23418854

If you know of a relevant reference for CRT 0066854 hydrochloride, please let us know.

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关键词: CRT 0066854 hydrochloride, CRT 0066854 hydrochloride supplier, CRT0066854, HCl, PKCiota, inhibitors, inhibits, protein, kinase, C, iota, PKCzeta, Protein, Kinase, 5922, Tocris Bioscience

1 篇 CRT 0066854 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CRT 0066854 hydrochloride 的部分引用包括：

Jann N et al (2021) Protein kinase Cι and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities. Cell Rep 37 110054 PMID: 34818553

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