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Submit ReviewCW 008 is a cAMP/PKA/CREB pathway activator. Promotes osteogenic differentiation of human bone marrow-derived MSCs in vitro. Increases bone mass and bone volume density in ovariectomized mice.
CW 008 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
分子量 | 420.37 |
公式 | C21H14F2N6O2 |
储存 | Store at +4°C |
纯度 | ≥98% (HPLC) |
CAS Number | 1134613-19-6 |
PubChem ID | 59528098 |
InChI Key | KCIMKTNQCUDTFI-UHFFFAOYSA-N |
Smiles | O=C(C1=CC=C(F)C=C1)NC2=NNC3=NC(C4=C5N(C=CC(OC)=C5)N=C4)=C(F)C=C32 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
DMSO | 21.02 | 50 |
以下数据基于产品分子量 420.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.5 mM | 4.76 mL | 23.79 mL | 47.58 mL |
2.5 mM | 0.95 mL | 4.76 mL | 9.52 mL |
5 mM | 0.48 mL | 2.38 mL | 4.76 mL |
25 mM | 0.1 mL | 0.48 mL | 0.95 mL |
参考文献是支持产品生物活性的出版物。
Kim et al (2013) An activator of the cAMP/PKA/CREB pathway promotes osteogenesis from human mesenchymal stem cells. J.Cell.Physiol. 228 617 PMID: 22886506
If you know of a relevant reference for CW 008, please let us know.
关键词: CW 008, CW 008 supplier, CW008, MSC, mesenchymal, stem, cells, protein, kinase, A, PKA, activators, CREB, cAMP, osteogenic, osteogenesis, activates, Protein, Kinase, Osteogenic, Stem, Cells, 5495, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 CW 008 的部分引用包括:
Yong et al (2021) Bisphenol S enhances gap junction intercellular communication in ovarian theca cells. Chemosphere 263 128304 PMID: 33155548
Yong et al (2021) A modified parachute assay for assessment of gap junction intercellular communication in placental trophoblast cells. Toxicol Mech Methods 31 393-399 PMID: 33784946
Xun et al (2023) Proteomes from AMPK-inhibited peripheral blood mononuclear cells suppress the progression of breast cancer and bone metastasis. Theranostics 13 1247-1263 PMID: 36923539
Karen E et al (2023) Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins. Elife 12 PMID: 36943734
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