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DCLK1-IN-1

Cat. No. 7285 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective doublecortin like kinase 1/2 (DCLK1/2) inhibitor; orally bioavailable
化学名： 5,11-Dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-5-(2,2,2-trifluoroethyl)-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for DCLK1-IN-1

DCLK1-IN-1 is a potent and selective doublecortin like kinase 1/2 (DCLK1/2) inhibitor (IC50 values are DCLK1 =9.5 and 57.2 nM and DCLK2 = 31 and 103 nM in binding and kinase assay, respectively). Exhibits no significant activity against ERK5, ACK, BRD4 and LRRK2. Exhibits DCLK inhibition in pancreatic ductal adenocarcinoma (PDAC) organoid models. Orally bioavailable.

许可信息

Sold under license from Dana-Farber Cancer Institute

External Portal Information for DCLK1-IN-1

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of DCLK1-IN-1 is reviewed on the chemical probes website.

化合物库 for DCLK1-IN-1

DCLK1-IN-1 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for DCLK1-IN-1

分子量 527.55
公式 C26H28F3N7O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2222635-15-4
PubChem ID 134457640
InChI Key OQFCHSFVWSLDAO-UHFFFAOYSA-N
Smiles COC1=C(C=CC(N2CCN(CC2)C)=C1)NC3=NC=C4N(C(C5=CC=CC=C5N(C4=N3)C)=O)CC(F)(F)F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DCLK1-IN-1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 52.76 100
ethanol 52.76 100

制备储备液 for DCLK1-IN-1

以下数据基于产品分子量 527.55。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.9 mL 9.48 mL 18.96 mL
5 mM 0.38 mL 1.9 mL 3.79 mL
10 mM 0.19 mL 0.95 mL 1.9 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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参考文献 for DCLK1-IN-1

参考文献是支持产品生物活性的出版物。

Ferguson et al (2020) Discovery of a selective inhibitor of doublecortin like kinase 1. Nat.Chem.Biol. 16 635 PMID: 32251410

If you know of a relevant reference for DCLK1-IN-1, please let us know.

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关键词: DCLK1-IN-1, DCLK1-IN-1 supplier, Potent, selective, doublecortin, like, kinase, 1/2, DCLK1/2, DCLK1, DCLK2, inhibitors, inhibits, Other, Kinases, 7285, Tocris Bioscience

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