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DLin-MC3-DMA

Cat. No. 7946 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Component of lipid nanoparticles (LNPs); ionizable cationic lipid
化学名： (6Z,9Z,28Z,31Z)-Heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate
纯度： ≥95% (HPLC)
说明书
引用文献
评论
实验方案 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for DLin-MC3-DMA

DLin-MC3-DMA is an ionizable cationic lipid (pKa = 6.44), used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for delivering cargos such as oligonucleotides into living cells. DLin-MC3-DMA can protect negatively charged cargos and facilitate their cytosolic transport.

For a fully formulate LNP containing DLin-MC3-DMA and a luciferase mRNA reporter, see MC3 LNP Luciferase (Cat. No. 8889).

For more information on how to prepare MC3 lipid nanoparticles for RNA delivery, please see our protocol.

技术数据 for DLin-MC3-DMA

分子量 642.09
公式 C43H79NO2
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 1224606-06-7
InChI Key NRLNQCOGCKAESA-KWXKLSQISA-N
Smiles C(OC(CCCN(C)C)=O)(CCCCCCCC/C=C\C/C=C\CCCCC)CCCCCCCC/C=C\C/C=C\CCCCC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DLin-MC3-DMA

溶解性 Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 100mg/mL)

参考文献 for DLin-MC3-DMA

参考文献是支持产品生物活性的出版物。

Han et al (2021) An ionizable lipid toolbox for RNA delivery. Nat.Commun 12 7233 PMID: 34903741

Semple et al (2010) Rational design of cationic lipids for siRNA delivery. Nat.Biotechnol 28 172 PMID: 20081866

Jayaraman et al (2012) Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo. Angew.Chem.Int.Ed.Engl 51 8529 PMID: 22782619

If you know of a relevant reference for DLin-MC3-DMA, please let us know.

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关键词: DLin-MC3-DMA, DLin-MC3-DMA supplier, DLinMC3DMA, unsaturated, ionizable, cationic, lipid, nanoparticles, LNP, cargo, delivery, cytosolic, transport, Biochemicals, and, Molecular, Biology, Lipid, Nanoparticles, 7946, Tocris Bioscience

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DLin-MC3-DMA 实验方案

以下实验方案包含使用 DLin-MC3-DMA（目录编号 7946）的更多信息。