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DLin-MC3-DMA

Cat. No. 7946 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Component of lipid nanoparticles (LNPs); ionizable cationic lipid
化学名： (6Z,9Z,28Z,31Z)-Heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate
纯度： ≥95% (HPLC)
说明书
引用文献
评论
实验方案 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for DLin-MC3-DMA

DLin-MC3-DMA is an ionizable cationic lipid (pKa = 6.44), used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for delivering cargos such as oligonucleotides into living cells. DLin-MC3-DMA can protect negatively charged cargos and facilitate their cytosolic transport.

For more information on how to prepare MC3 lipid nanoparticles for RNA delivery, please see our protocol.

技术数据 for DLin-MC3-DMA

分子量 642.09
公式 C43H79NO2
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 1224606-06-7
InChI Key NRLNQCOGCKAESA-KWXKLSQISA-N
Smiles C(OC(CCCN(C)C)=O)(CCCCCCCC/C=C\C/C=C\CCCCC)CCCCCCCC/C=C\C/C=C\CCCCC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DLin-MC3-DMA

溶解性 Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 100mg/mL)

参考文献 for DLin-MC3-DMA

参考文献是支持产品生物活性的出版物。

Han et al (2021) An ionizable lipid toolbox for RNA delivery. Nat.Commun 12 7233 PMID: 34903741

Semple et al (2010) Rational design of cationic lipids for siRNA delivery. Nat.Biotechnol 28 172 PMID: 20081866

Jayaraman et al (2012) Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo. Angew.Chem.Int.Ed.Engl 51 8529 PMID: 22782619

If you know of a relevant reference for DLin-MC3-DMA, please let us know.

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关键词: DLin-MC3-DMA, DLin-MC3-DMA supplier, DLinMC3DMA, unsaturated, ionizable, cationic, lipid, nanoparticles, LNP, cargo, delivery, cytosolic, transport, Biochemicals, and, Molecular, Biology, Lipid, Nanoparticles, 7946, Tocris Bioscience

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DLin-MC3-DMA 实验方案

以下实验方案包含使用 DLin-MC3-DMA（目录编号 7946）的更多信息。