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DMG-PEG 2000

Cat. No. 7944 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： PEGylated myristoyl diglyceride; commonly used in the formation of lipid nanoparticles (LNPs)
化学名： 1,2-Dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000
纯度： ≥90% (HPLC)
说明书
引用文献
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实验方案 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for DMG-PEG 2000

DMG-PEG 2000 is a PEGylated myristoyl diglyceride consisting of one unbranched PEG 2000 chain and two saturated fatty acid chains (C14:0) covalently attached to a glycerol. DMG-PEG 2000 is commonly used in the formation of lipid nanoparticles (LNPs) and liposomes to prevent serum protein adsorption, nanoparticle aggregation and increase in vivo circulation time. DMG-PEG 2000 is a component of LNPs which can be used for delivery of RNA-based vaccines or mRNA therapeutics.

For more information on how to prepare MC3 lipid nanoparticles for RNA delivery, please see our protocol.

技术数据 for DMG-PEG 2000

公式 (C2H4O)nC32H62O5
储存 Store at -20°C
纯度 ≥90% (HPLC)
CAS Number 160743-62-4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DMG-PEG 2000

溶解性 Soluble to 10 mg/ml in ethanol and to 10 mg/ml in chloroform

参考文献 for DMG-PEG 2000

参考文献是支持产品生物活性的出版物。

Cheng et al (2018) Dendrimer-based lipid nanoparticles deliver therapeutic FAH mRNA to normalize liver function and extend survival in a mouse model of hepatorenal tyrosinemia type I. Adv.Mater. 30 e1805308 PMID: 30368954

Zhang et al (2020) Functionalized lipid-like nanoparticles for in vivo mRNA delivery and base editing. Sci.Adv. 6 eabc2315 PMID: 32937374

If you know of a relevant reference for DMG-PEG 2000, please let us know.

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DMG-PEG 2000 实验方案

以下实验方案包含使用 DMG-PEG 2000（目录编号 7944）的更多信息。