DSPE-PEG 2000 Maleimide

Cat. No. 7947 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： PEGylated DSPE with a maleimide reactive group

化学名： 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol-2000)]

纯度： ≥90% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for DSPE-PEG 2000 Maleimide

DSPE-PEG 2000 Maleimide is a functionalized phospholipid-polymer conjugate. It comprises a 1,2-distearoyl-sn-glycero-PE (DSPE) covalently coupled to a linear polyethylene glycol (M_r 2000) with a maleimide-terminated end for onward chemistry. It is commonly used to synthesize antibody-coupled liposomes and lipid nanoparticles. It has been used in antibody-targeted LNP-mRNA systems to generate transient antifibrotic chimeric antigen receptor (CAR) T cells in vivo.

技术数据 for DSPE-PEG 2000 Maleimide

公式	(C₂H₄O)_nC₅₁H₉₁N₃O₁₃P.NH₄ or Na
储存	Store at -20°C
纯度	≥90% (HPLC)

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DSPE-PEG 2000 Maleimide

溶解性	Soluble to 10 mg/ml in ethanol with gentle warming and to 10 mg/ml in chloroform

产品说明书 for DSPE-PEG 2000 Maleimide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for DSPE-PEG 2000 Maleimide

参考文献是支持产品生物活性的出版物。

Ishida et al (1999) A combinatorial approach to producing sterically stabilized (Stealth) immunoliposomal drugs. FEBS Lett. 460 129 PMID: 10571074

Rurik et al (2022) CAR T cells produced in vivo to treat cardiac injury. Science 375 91 PMID: 34990237

Herrera-Barrera et al (2023) Peptide-guided lipid nanoparticles deliver mRNA to the neural retina of rodents and nonhuman primates. Sci.Adv. 9 eadd4623 PMID: 36630502

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